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US 10,449,536 B2Granted
Diagnostic devices with modifiable hydrophobic surfaces
AssigneeSiemens Healthcare Diagnostics Inc.
InventorJohn Perng
Life of this patent
Estimating the term…
Abstract
A diagnostic device 10 for screening for a target analyte in a sample is provided. The diagnostic device 10 comprises a substrate 12 and a hydrophobic material 20 disposed on the substrate. The hydrophobic material 20 is selected to be converted from the hydrophobic material 20 to a hydrophilic material 22 upon contact with a conversion component within or derived from a sample introduced to the device 10.
Claims18
A diagnostic device comprising:
- a substrate;
- and
- a hydrophobic material disposed on the substrate;
- wherein the hydrophobic material is selected to be converted from the hydrophobic material to a hydrophilic material upon contact with a conversion component within or derived from a sample introduced to the device, wherein the conversion component comprises carbon dioxide;
- and
- wherein the substrate comprises a plurality of reaction channels, and wherein at least some of the plurality of reaction channels comprise an amount of the hydrophobic material therein, and wherein the plurality of reaction channels each comprise a dye at an end of the respective channels, wherein the dye is selected to provide a visible or readable indication that a sample introduced to the device has traveled along a length of the reaction channel to the dye.
3 more elements
A diagnostic device comprising:
- a substrate;
- and
- a hydrophobic material disposed on the substrate;
- wherein the hydrophobic material is selected to be converted from the hydrophobic material to a hydrophilic material upon contact with a conversion component within or derived from a sample introduced to the device, wherein the conversion component comprises a compound having a thiol-terminated group;
- and
- wherein the substrate comprises a plurality of reaction channels, and wherein at least some of the plurality of reaction channels comprise an amount of the hydrophobic material therein, and wherein the plurality of reaction channels each comprise a dye at an end of the respective channels, wherein the dye is selected to provide a visible or readable indication that a sample introduced to the device has traveled along a length of the reaction channel to the dye.
3 more elements
A diagnostic device comprising:
- a substrate;
- and
- a hydrophobic material disposed on the substrate;
- wherein the hydrophobic material is selected to be converted from the hydrophobic material to a hydrophilic material upon contact with a conversion component within or derived from a sample introduced to the device, wherein the conversion component comprises glutathione;
- and
- wherein the substrate comprises a plurality of reaction channels, and wherein at least some of the plurality of reaction channels comprise an amount of the hydrophobic material therein, and wherein the plurality of reaction channels each comprise a dye at an end of the respective channels, wherein the dye is selected to provide a visible or readable indication that a sample introduced to the device has traveled along a length of the reaction channel to the dye.
3 more elements
Dependencies are inferred from the claim text.