Zika RNA vaccines
AssigneeModernaTX, Inc.
InventorsGiuseppe Ciaramella, Eric Yi-Chun Huang, Kapil Bahl, Tal Zaks, Sunny Himansu
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Abstract
Aspects of the disclosure describe compositions that comprise RNA polynucleotides having an open reading frame encoding one or more Zika virus antigens. Methods for preparing and using the compositions are also described.
Claims27
A Zika virus (ZIKV) immunogenic composition, comprising:
- a messenger ribonucleic acid (mRNA) polynucleotide having an open reading frame encoding a ZIKV antigenic polypeptide formulated in a lipid nanoparticle.
A method of inducing an immune response in a subject, the method comprising administering to the subject a ZIKV immunogenic composition comprising a messenger ribonucleic acid (mRNA) polynucleotide having an open reading frame encoding a ZIKV antigenic polypeptide, in an amount effective to produce an antigen-specific immune response in the subject.
A Zika virus (ZIKV) immunogenic composition, comprising a ribonucleic acid (RNA) polynucleotide having an open reading frame encoding a ZIKV antigenic polypeptide, a 5′ terminal cap, and a chemical modification, wherein the immunogenic composition is formulated within a lipid nanoparticle.
A Zika virus (ZIKV) immunogenic composition, comprising a messenger ribonucleic acid (mRNA) polynucleotide having an open reading frame encoding a ZIKV polypeptide linked to a signal peptide.
Dependencies are inferred from the claim text.