Dendritic macroporous hydrogels prepared by crystal templating
AssigneeBoard of Regents, The University of Texas System
InventorsScott Zawko, Christine Schmidt
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Abstract
The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.
Claims20
An apparatus comprising:
- a hydrogel film having first and second opposing ends;
- wherein the hydrogel film includes (a)(i) uncrosslinked hyaluronic acid, (a)(ii) crosslinked alginate, and (a)(iii) at least one of a protein or a biomineral;
- wherein (b)(i) the alginate is crosslinked with calcium, and (b)(ii) the alginate is crosslinked around the uncrosslinked hyaluronic acid.
An apparatus comprising:
- a hydrogel film having first and second opposing ends;
- wherein the hydrogel film includes (a)(i) uncrosslinked hyaluronic acid, (a)(ii) crosslinked alginate, and (a)(iii) a protein;
- wherein (b)(i) the alginate is crosslinked with an ion, and (b)(ii) the alginate is crosslinked around the uncrosslinked hyaluronic acid.
An apparatus comprising:
- a hydrogel film having first and second opposing ends;
- wherein the hydrogel film includes (a)(i) uncrosslinked hyaluronic acid, (a)(ii) crosslinked alginate, and (a)(iii) an amide;
- wherein (b)(i) the alginate is crosslinked with an ion, and (b)(ii) the alginate is crosslinked around the uncrosslinked hyaluronic acid.
Dependencies are inferred from the claim text.