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US 10,442,852 B2Granted
Methods and compositions for treatment of symptoms associated with intracranial hemorrhage
AssigneeBoard of Regents, The University of Texas System
InventorsMarian L. Kruzel, Jaroslaw Aronowski
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Abstract
Methods and compositions are provided for the treatment of a patient with intracranial hemorrhage (ICH). Methods include the use of the products of recombinant constructs such as those that contain lactoferrin, as well as fusion protein constructs of lactoferrin and Fc domain for IgG.
Claims11
A recombinant polypeptide comprising:
- a lactoferrin sequence;
- an immunoglobulin IgG2 Fc domain sequence fused to said lactoferrin sequence;
- and
- an IgG2 hinge sequence, wherein said hinge is located between said lactoferrin sequence and said Fc domain sequence,
- wherein the amino acid sequence of said recombinant polypeptide has a sequence of SEQ ID NO:
- 2.
3 more elements
An isolated recombinant polynucleotide molecule comprising a coding sequence for a polypeptide comprising:
- a lactoferrin coding sequence;
- an immunoglobulin IgG2 Fc domain coding sequence fused to said lactoferrin coding sequence;
- and
- an IgG2 hinge coding sequence, wherein said hinge is located between said lactoferrin coding sequence and said Fc domain coding sequence;
- and
- wherein polypeptide has a sequence of SEQ ID NO:
- 2.
4 more elements
Dependencies are inferred from the claim text.