# US 10,441,822 B2 · Skincare compositions

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- Number: US 10,441,822 B2
- Document ID: US10441822B2
- Status: Granted
- Kind: B2
- Application number: 15/988,595
- Filed: 2018-05-24
- Published: 2018-09-20
- Granted: 2019-10-15
- Earliest claimed: 2009-07-17
- Assignees: Reckitt Benckiser Healthcare International Limited
- Applicants: Reckitt Benckiser Healthcare International Limited
- Inventors: Carolyn Buckley; Stuart Jackson; Neil Kilcullen; Diane Marie Pavis
- Web page: https://patentgrep.com/patent/US10441822B2

## CPC

- A61K 8/0208: {Tissues; Wipes; Patches}
- A61K 8/34: Alcohols
- A61K 8/365: Hydroxycarboxylic acids; Ketocarboxylic acids
- A61K 8/368: with carboxyl groups directly bound to carbon atoms of aromatic rings
- A61K 8/442: {substituted by amido group(s)}
- A61K 8/4913: {having five membered rings, e.g. pyrrolidone carboxylic acid}
- A61K 8/4946: {Imidazoles or their condensed derivatives, e.g. benzimidazoles}
- A61K 8/602: {Glycosides, e.g. rutin}
- A61K 8/63: Steroids; Derivatives thereof
- A61K 8/675: {Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde (tocopheryl nicotinate A61K8/678)}
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 31/045: Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- A61K 31/4166: having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
- A61K 31/60: Salicylic acid; Derivatives thereof
- A61K 36/185: Magnoliopsida (dicotyledons)
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 17/10: Anti-acne agents
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 31/04: Antibacterial agents
- A61P 31/10: Antimycotics
- A61P 31/12: Antivirals
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/008: {Preparations for oily skin}
- A61K 2800/28: Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

This invention relates to skincare compositions, in particular compositions effective in the treatment of acne vulgaris, and to methods of treatment of the skin that involve the application of such compositions, wherein the compositions comprise salicylic acid or a salt thereof in combination with at least two actives selected from the group consisting of lactic acid or a salt thereof; glycyrrhizinic acid or a salt or a derivative thereof; bisabolol; cetylhydroxyproline palmitamide; allantoin; niacinamide; and Epilobium angustifolium extract.

## Claims

### Claim 1

A cosmetic method for improving the appearance of skin afflicted by acne lesions, said method comprising reducing the redness of said lesions by the topical application of a skincare composition consisting of:
salicylic acid or a salt thereof in a concentration of 2 wt %;
glycyrrhizinic acid or a salt thereof in a concentration of 0.05 wt %;
cetylhydroxyproline palmitamide in a concentration of 0.025 wt %;
lactic acid or a salt thereof in a concentration of 1.998 wt %;
bisabolol in a concentration of 0.025 wt %;
niacinamide in a concentration of 2 wt %;
a chelating agent in a concentration of 0.01 wt % to 0.1 wt %;
a gelling/thickening agent in a concentration of 0.1 wt % to 5 wt %;
an emulsifier in a concentration of 0.75 wt % to 12 wt %;
a mixed solvent system comprising water and a co-solvent wherein the co-solvent is present in a concentration of 0 wt % to about 5 wt % and the water forms the remainder of the composition;
an emollient in a concentration of 0 wt % to 8 wt %;
a humectant or moisturizer in a concentration of 0 wt % to 10 wt %;
a surfactant in a concentration of 0 wt % to about 38 wt %;
a preservative in a concentration of 0 wt % to 0.3 wt %;
an abrasive in a concentration of 0 wt % to 8.5 wt %;
an opacifying agent in a concentration of 0 wt % to 15 wt %;
a pH adjuster in a concentration of 0 wt % to 3 wt %;
a conditioning agent in a concentration of 0 wt % to 1.5 wt %;
a perfume in a concentration of 0 wt % to 0.35 wt %; and
a coloring in a concentration of 0 wt % to 0.00315 wt %,
wherein the composition has a viscosity of from about 10,000 mPa/s to about 200,000 mPa/s.

### Claim 2 (depends on 1)

The method as claimed in claim 1, wherein the pH of the skincare composition is in the range from 3.5 to 6.0.

### Claim 3 (depends on 1)

The method as claimed in claim 1, wherein the skincare composition has the form of one of an aqueous solution surfactant wash, an oily solution surfactant wash, a dispersion, an emulsion, or a gel.

### Claim 4 (depends on 3)

The method as claimed in claim 3, wherein the skincare composition has the form of an emulsion comprising an oil-in-water emulsion.

### Claim 5 (depends on 3)

The method as claimed in claim 3, wherein the skincare composition has the form of a gel comprising an aqueous gel.

### Claim 6 (depends on 1)

An article comprising a fibrous substrate configured for topical application of the skincare composition according to claim 1.

### Claim 7 (depends on 6)

The article as claimed in claim 6, the fibrous substrate selected from the group consisting of cellulose fibers, cotton fibers, and a mixture thereof.

### Claim 8 (depends on 1)

A method for the treatment of acne comprising:
topically applying a skincare composition according to claim 1 to the skin of a patient.

### Claim 9 (depends on 8)

The method as claimed in claim 8, which is a cosmetic method.

### Claim 10 (depends on 8)

The method as claimed in claim 8, which is a therapeutic method.

### Claim 11 (depends on 1)

The use of the composition according to claim 1 in a composition for the treatment of acne by topical application of the composition to the skin.

### Claim 12 (depends on 1)

A method for reducing irritancy associated with the topical application of a skincare composition comprising topical application of a skincare composition according to claim 1.

### Claim 13 (depends on 1)

A cosmetic method for improving the appearance of skin afflicted by acne lesions comprising reducing the redness of lesions by the topical application of a skincare composition according to claim 1.

### Claim 14 (depends on 3)

The method as claimed in claim 3, wherein the skincare composition has the form of an emulsion selected from the group consisting of an oil-in-water emulsion, a water-in-oil emulsion, and a microemulsion.