# US 10,441,808 B2 · Methods and devices for activating brown adipose tissue with light > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,441,808 B2 - Document ID: US10441808B2 - Status: Granted - Kind: B2 - Application number: 13/977,536 - Filed: 2011-12-21 - Published: 2014-03-27 - Granted: 2019-10-15 - Earliest claimed: 2010-12-29 - Assignees: Ethicon Endo-Surgery, Inc.; The General Hospital Corporation - Applicants: Jason L. Harris; Lee M. Kaplan; David N. Plescia; Taylor W. Aronhalt; James W. Voegele; Nicholas Stylopoulos - Inventors: Jason L. Harris; Lee M. Kaplan; David N. Plescia; Taylor W. Aronhalt; James W. Voegele; Nicholas Stylopoulos - Web page: https://patentgrep.com/patent/US10441808B2 ## CPC - A61N 5/0613: {Apparatus adapted for a specific treatment} - A61M 5/14276: {specially adapted for implantation} - A61N 5/062: {Photodynamic therapy, i.e. excitation of an agent} - A61M 2230/06: Heartbeat rate only - A61M 2230/201: Glucose concentration - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract Methods and devices are provided for activating brown adipose tissue (BAT) with light. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a medical device is provided that activates BAT by using light to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The light can be configured to directly or indirectly stimulate the nerves and/or the brown adipocytes. The light can be configured to indirectly stimulate the nerves and/or the brown adipocytes by activating a light activatable medium administered to a patient and configured to respond to the light to cause activation of the brown adipose tissue. ## Claims ### Claim 1 A medical method, comprising: positioning a housing in contact with tissue of a patient, the housing having housed therein a light source operatively positioned proximate to a depot of brown adipose tissue; activating the light source to deliver light energy to the patient to activate the brown adipose tissue and increase energy expenditure of the brown adipose tissue; after the activating, sensing with a sensor a characteristic of the brown adipose tissue and transmitting the sensed characteristic to a controller operatively coupled to the light source; changing, with the controller, the light energy being delivered by the light source based on the sensed characteristic, wherein the changing includes either turning off the light source to stop delivering the light energy or altering at least one of pulse duration, power, duty cycle, frequency of delivery, and wavelength of the light energy; delivering a light activatable medium to the depot of brown adipose tissue, the light activatable medium being configured to respond to the light energy when the light energy is delivered to the patient, the response of the light activatable medium causing activation of the brown adipose tissue; and delivering a different light activatable medium to the depot of brown adipose tissue, wherein: the housing has an additional light source housed therein positioned proximate to the depot of brown adipose tissue; the method further comprises activating the additional light source to deliver additional light energy to the patient to activate the brown adipose tissue and increase energy expenditure of the brown adipose tissue; the light energy has a first wavelength and the additional light energy has a different wavelength; the light activatable medium is activated by the first wavelength but is not activatable by the different wavelength; and the different light activatable medium is activated by the different wavelength but is not activatable by the first wavelength. ### Claim 2 (depends on 1) The method of claim 1, wherein the first wavelength of the light energy is in an infrared range of about 0.7 to 1000 μm. ### Claim 3 (depends on 1) The method of claim 1, wherein the first wavelength of the light energy is in an ultraviolet range of about 0.01 to 0.4 μm. ### Claim 4 (depends on 1) The method of claim 1, wherein delivering the light activatable medium to the depot of brown adipose tissue comprises alternating at least once between delivering the light activatable medium to the patient during a first period of time and not delivering the light activatable medium to the patient during a second period of time. ### Claim 5 (depends on 1) The method of claim 1, further comprising targeting the light energy to a nerve innervating the brown adipose tissue to activate the brown adipose tissue. ### Claim 6 (depends on 1) The method of claim 1, wherein the depot of brown adipose tissue is in a supraclavicular region of the patient. ### Claim 7 (depends on 1) The method of claim 1, wherein positioning the housing in contact with tissue of the patient comprises transcutaneously applying the housing to an exterior skin surface of the patient. ### Claim 8 (depends on 1) The method of claim 1, wherein positioning the housing in contact with tissue of the patient comprises subcutaneously positioning at least a portion of the housing within the patient. ### Claim 9 (depends on 1) The method of claim 1, wherein the light energy delivered by the light source is continuously delivered to the patient for a predetermined amount of time in a range of one day to four weeks. ### Claim 10 (depends on 9) The method of claim 9, further comprising after the light energy has been continuously delivered to the patient for the predetermined amount of time, removing the housing from the patient; repositioning the housing in contact with tissue of the patient with the light source proximate to another depot of brown adipose tissue; and activating the light source to deliver additional light energy by the light source to the patient to activate the other depot of brown adipose tissue and increase energy expenditure of the other depot of brown adipose tissue. ### Claim 11 (depends on 10) The method of claim 10, wherein the depot of brown adipose tissue is in a supraclavicular region on one of a left and right side of a sagittal plane of the patient, and the other depot of brown adipose tissue is in a supraclavicular region on the other of the left and right side of the sagittal plane of the patient. ### Claim 12 (depends on 10) The method of claim 10, further comprising, after the additional light energy has been delivered to the patient, in response to a trigger event, removing the housing from contact with tissue of the patient proximate to the other depot of brown adipose tissue and repositioning the housing to be in contact with another area of tissue of the patient with the light source proximate to a third depot of brown adipose tissue, wherein the trigger event includes at least one of the patient eating, the patient resting, a threshold temperature of the patient, a directional orientation of the patient, a change in the patient's weight, a change in the patient's tissue impedance, manual activation by the patient or other human, and a blood chemistry change in the patient. ### Claim 13 (depends on 9) The method of claim 9, wherein the predetermined amount of time is at least seven days. ### Claim 14 (depends on 9) The method of claim 9, further comprising waiting a second predetermined amount of time after the light source has delivered the light energy to the patient and then activating the light source to deliver additional light energy to the patient to activate the depot of brown adipose tissue and increase energy expenditure of the brown adipose tissue. ### Claim 15 (depends on 1) The method of claim 1, wherein the characteristic of the depot of brown adipose tissue includes at least one of temperature and an electrical signal.