# US 10,441,788 B2 · Methods and devices for neuromodulation of the adrenal gland

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- Number: US 10,441,788 B2
- Document ID: US10441788B2
- Status: Granted
- Kind: B2
- Application number: 15/683,750
- Filed: 2017-08-22
- Published: 2018-03-01
- Granted: 2019-10-15
- Earliest claimed: 2016-08-23
- Assignees: Boston Scientific Neuromodulation Corporation
- Applicants: Boston Scientific Neuromodulation Corporation
- Inventors: Lynne E. Swanson; William C. Stoffregen; Bryan A. Clark; Michael X. Govea; Dennis B. Werner; Natalie A. Brill; Pramodsingh H. Thakur
- Web page: https://patentgrep.com/patent/US10441788B2

## CPC

- A61N 1/3606: {adapted for a particular treatment}
- A61B 5/4836: {Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence)}
- A61B 5/686: {Permanently implanted devices, e.g. pacemakers, other stimulators, biochips (A61B5/6861 takes precedence)}
- A61N 1/36135: {using physiological parameters}
- A61N 1/36185: {Selection of the electrode configuration}
- A61B 5/01: Measuring temperature of body parts {; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue} (clinical contact thermometers G01K13/20)
- A61B 5/0215: by means inserted into the body
- A61B 5/024: Measuring pulse rate or heart rate
- A61B 5/02405: {Determining heart rate variability}
- A61B 5/029: Measuring blood output from the heart, e.g. minute volume
- A61B 5/0816: {Measuring devices for examining respiratory frequency (measuring frequency of electric signals G01R23/00)}
- A61B 5/14546: {for measuring analytes not otherwise provided for, e.g. ions, cytochromes}
- A61B 5/1473: invasive, e.g. introduced into the body by a catheter
- A61B 5/4227: {endocrine glands, i.e. thyroid, adrenals, hypothalamic, pituitary}
- A61B 5/4561: {Evaluating static posture, e.g. undesirable back curvature (A61B5/1116 takes precedence)}
- A61B 5/4809: {Sleep detection, i.e. determining whether a subject is asleep or not}
- A61F 7/007: {characterised by electric heating}
- A61F 7/12: Devices for heating or cooling internal body cavities
- A61F 2007/0075: {using a Peltier element, e.g. near the spot to be heated or cooled}
- A61F 2007/126: {for invasive application, e.g. for introducing into blood vessels}
- A61N 1/0553: {Paddle shaped electrodes, e.g. for laminotomy}
- A61N 1/0558: {Anchoring or fixation means therefor}
- A61N 1/36007: {of urogenital or gastrointestinal organs, e.g. for incontinence control}
- A61N 1/36171: {Frequency}
- A61N 1/36175: {Pulse width or duty cycle}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)

## Abstract

Aspects of the present disclosure are directed toward apparatuses, systems, and methods for delivering therapy to an adrenal gland of a patient. The apparatuses, systems, and methods may include a lead body that attaches to a portion of the adrenal gland of the patient; and a plurality of electrodes arranged along the lead body. In addition, one or more of the plurality of electrodes may deliver stimulation energy to modulate catecholamine release from chromaffin cells within the adrenal gland.

## Claims

### Claim 1

A method of delivering therapy to an adrenal gland of a patient, the method comprising:
delivering a lead body to the adrenal gland of the patient, the lead body including a plurality of electrodes arranged in an array on a paddle component at a distal end of the lead body;
attaching a portion of the lead body to a capsule of the adrenal gland or pericapsular connective tissue of the patient including arranging the paddle component between the capsule and the adrenal gland; and
delivering stimulation energy through at least one of the plurality of electrodes arranged along the lead body to modulate catecholamine release from chromaffin cells within the adrenal gland.

### Claim 2 (depends on 1)

The method of claim 1, wherein attaching the portion of the lead body to the capsule comprises attaching the portion the lead body by using at least one of mechanical attachment and adhesive attachment.

### Claim 3 (depends on 2)

The method of claim 2, wherein mechanically attaching the portion of the lead body further includes attaching the lead body to the capsule using a barb, a suture tab, a helix, and a talon arranged with the portion of the lead body.