# US 10,441,685 B2 · Biomedical patches with spatially arranged fibers

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- Number: US 10,441,685 B2
- Document ID: US10441685B2
- Status: Granted
- Kind: B2
- Application number: 16/131,887
- Filed: 2018-09-14
- Published: 2019-01-17
- Granted: 2019-10-15
- Earliest claimed: 2018-09-14
- Assignees: Washington University
- Applicants: Washington University
- Inventors: Matthew R. MacEwan
- Web page: https://patentgrep.com/patent/US10441685B2

## CPC

- A61L 31/04: Macromolecular materials
- A61F 13/00987: {Apparatus or processes for manufacturing non-adhesive dressings or bandages}
- A61F 13/01017: {synthetic, e.g. polymer based}
- A61F 13/01034: {characterised by a property}
- A61L 15/26: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof {(A61L15/225 takes precedence)}
- A61L 15/44: Medicaments
- A61L 15/64: specially adapted to be resorbable inside the body
- A61L 27/18: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61L 27/58: Materials at least partially resorbable by the body
- A61L 27/60: Materials for use in artificial skin
- B29C 48/18: the components being layers
- B32B 5/022: {Non-woven fabric}
- B32B 5/26: another layer {next to it} also being fibrous or filamentary {(relative arrangement of fibres or filaments of different layers B32B5/12)}
- B32B 7/02: Physical, chemical or physicochemical properties
- B32B 7/12: using interposed adhesives or interposed materials with bonding properties
- D01D 5/0007: {Electro-spinning (non-woven fabrics produced by electro-spinning D04H1/728)}
- D01D 5/0038: {the fibre formed by solvent evaporation, i.e. dry electro-spinning}
- D01D 5/0061: {characterised by the electro-spinning apparatus}
- D01D 5/0076: {characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid (D01D5/0046 takes precedence)}
- D04H 1/4374: using different kinds of webs, e.g. by layering webs
- D04H 1/728: by electro-spinning {(electro-spinning methods and apparatus D01D5/0007)}
- D04H 3/16: with bonds between thermoplastic filaments produced in association with filament formation, e.g. immediately following extrusion
- A61F 13/02: Adhesive bandages or dressings
- A61L 2300/414: Growth factors
- A61L 2400/12: Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
- A61L 2400/18: Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
- A61L 2430/20: for reconstruction of the heart, e.g. heart valves
- A61L 2430/32: for nerve reconstruction
- B32B 2250/20: All layers being fibrous or filamentary
- B32B 2262/0276: Polyester fibres
- B32B 2307/518: bi-axially
- B32B 2307/54: Yield strength; Tensile strength
- B32B 2307/726: Permeability to liquids, absorption
- B32B 2307/7265: Non-permeable
- B32B 2556/00: Patches, e.g. medical patches, repair patches
- D10B 2509/00: Medical; Hygiene
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- B29C: SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING (making preforms B29B11/00; making laminated products by combining previously unconnected layers which become one product whose layers will remain together B32B37/00 - B32B41/00)
- B32B: LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- D01D: MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D04H: MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL (weaving D03; knitting D04B; braiding D04C; net-making D04G; sewing D05B; tufting D05C; finishing non-woven fabrics D06); FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING {; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION}(non-woven fabrics having an intermediate or external layer of a different kind, e.g. of woven fabric, B32B)
- D10B: INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES

## Abstract

A system and methods for producing a structure including a plurality of fibers is provided. The system includes a polymer collector having a predefined pattern, wherein the collector is charged at a first polarity, and a spinneret configured to dispense a polymer, wherein the spinneret is charged at a second polarity substantially opposite the first polarity such that polymer dispensed from the spinneret forms a plurality of fibers on the predefined pattern of the fiber collector.

## Claims

### Claim 1

A method for producing a structure for use in repairing a defect in a substrate, the method comprising:
providing a first layer formed by a plurality of polymeric fibers;
providing a second layer formed by a plurality of polymeric fibers, the second layer having a plurality of densities; and
coupling the first layer and the second layer together using a first coupling process such that the first and second layers are configured to separate after at least one of a predetermined time and an environmental condition.

### Claim 2 (depends on 1)

A method in accordance with claim 1, wherein using a first coupling process includes at least one of heating, applying mechanical stress, applying mechanical pressure, applying a glue, chemical processing, cross-linking, and surface functionalization.

### Claim 3 (depends on 1)

A method in accordance with claim 1, wherein providing a first layer further comprises providing a first layer that is configured to be applied to biological tissue.

### Claim 4 (depends on 1)

A method in accordance with claim 1, wherein providing a second layer further comprises providing a second layer that is configured to be applied to biological tissue.

### Claim 5 (depends on 1)

A method in accordance with claim 1, further comprising providing a third layer formed by a plurality of polymeric fibers.

### Claim 6 (depends on 5)

A method in accordance with claim 5, further comprising coupling the third layer to at least one of the first layer and the second layer by a second coupling process that is different from the first coupling process.

### Claim 7 (depends on 5)

A method in accordance with claim 5, further comprising coupling the third layer to least one of the first layer and the second layer by the first coupling process.

### Claim 8 (depends on 1)

A method in accordance with claim 1, further comprising:
providing a backing that is at least one of permeable and non-permeable; and
coupling the backing to at least one of the first layer and the second layer.