# US 10,441,658 B2 · Ophthalmic composition

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- Number: US 10,441,658 B2
- Document ID: US10441658B2
- Status: Granted
- Kind: B2
- Application number: 16/279,129
- Filed: 2019-02-19
- Published: 2019-06-20
- Granted: 2019-10-15
- Earliest claimed: 2014-10-31
- Assignees: Johnson & Johnson Consumer Inc.
- Applicants: Johnson & Johnson Consumer Inc.
- Inventors: Mingqi Bai; Kenneth T. Holeva
- Web page: https://patentgrep.com/patent/US10441658B2

## CPC

- A61K 47/12: Carboxylic acids; Salts or anhydrides thereof
- A61K 9/0048: {Eye, e.g. artificial tears}
- A61K 9/08: Solutions {(composition of solutions A61K47/00)}
- A61K 31/715: Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K 31/717: Celluloses
- A61K 31/728: Hyaluronic acid
- A61K 31/77: of oxiranes
- A61K 31/78: of acrylic acid or derivatives thereof
- A61K 31/785: Polymers containing nitrogen
- A61K 47/32: Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone}
- A61K 47/34: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence)
- A61K 47/36: Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61P 27/02: Ophthalmic agents
- A61P 27/04: Artificial tears; Irrigation solutions
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to ophthalmic compositions for treatment of conditions in the eye. More specifically, the present invention relates to ophthalmic compositions comprising a polyquaternium compound and an anionic polymer. Methods for reducing and/or preventing the incompatibility of polyquaternium compounds with anionic polymers are also disclosed.

## Claims

### Claim 1

A method of reducing the precipitation of a polyquaternium compound and an anionic polymer in a composition ophthalmologically suitable for application to the eyes comprising such compounds, comprising the steps of:
i) providing from about 0.001% to about 0.5% of an anionic polymer having a weight average molecular weight of from about 250 to about 4,000,000 Daltons;
ii) adding an effective amount of an organic acid, salts thereof or mixtures thereof, such that the organic acid binds with the monomer units of the polyquaternium compound at at least a 1:1 molar ratio; and
iii) adding from about 10 ppm to about 1000 ppm of a polyquaternium compound having a weight average molecular weight of from about 150 to about 15,000 Daltons;
wherein the composition is substantially free of cationic oligomer compounds and precipitation inhibiting compounds.