# US 10,441,625 B2 · Materials and methods for treatment of inflammation

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- Number: US 10,441,625 B2
- Document ID: US10441625B2
- Status: Granted
- Kind: B2
- Application number: 16/035,274
- Filed: 2018-07-13
- Published: 2018-11-01
- Granted: 2019-10-15
- Earliest claimed: 2010-05-21
- Assignees: Cytogel Pharma, LLC
- Applicants: Cytogel Pharma, LLC
- Inventors: Theodore E. Maione; Constantine Basil Maglaris
- Web page: https://patentgrep.com/patent/US10441625B2

## CPC

- A61K 38/07: Tetrapeptides
- A61K 38/04: Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof ({enzyme inhibitors A61K38/005;} gastrins {A61K38/2207}, somatostatins A61K38/31, melanotropins A61K38/34 {; protease inhibitors A61K38/55})
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 1/04: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A61P 5/00: Drugs for disorders of the endocrine system
- A61P 7/10: Antioedematous agents; Diuretics
- A61P 11/06: Antiasthmatics
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 17/06: Antipsoriatics
- A61P 17/18: Antioxidants, e.g. antiradicals (preparations for protection against sunlight A61Q17/00)
- A61P 19/00: Drugs for skeletal disorders
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 19/08: for bone diseases, e.g. rachitism, Paget's disease
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/02: for peripheral neuropathies
- A61P 25/04: Centrally acting analgesics, e.g. opioids
- A61P 25/06: Antimigraine agents
- A61P 25/30: for treating abuse or dependence
- A61P 25/36: Opioid-abuse
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/04: Antibacterial agents
- A61P 37/00: Drugs for immunological or allergic disorders
- A61P 37/06: Immunosuppressants, e.g. drugs for graft rejection
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The subject invention pertains to peptides and salts thereof that are useful as anti-inflammatory agents and to compositions containing such peptides and salts as active ingredients. Specifically exemplified herein are endomorphin-1 peptide (EM-1), analogs and salts thereof, and uses for modulation of calcitonin gene-related peptide (CGRP) production and/or substance P (SP) and for treatment of inflammation, particularly neurogenic inflammation.

## Claims

### Claim 1

A method for treating a human subject to reduce neurogenic inflammation, wherein said method comprises administering, intravenously, to a human subject in need of treatment of neurogenic inflammation, an effective amount of the acetate salt of SEQ ID NO:13.

### Claim 2 (depends on 1)

The method, according to claim 1, further comprising administering an anti-inflammatory agent selected from the group consisting of a steroidal compound, hydrocortisone, a non-steroidal anti-inflammatory compound, acetylsalicylic acid (aspirin), ibuprofen, acetaminophen, and indomethacin, wherein the anti-inflammatory agent is administered before, during, or after the administration of said peptide or salt thereof.