# US 10,441,623 B2 · Dietary composition and method for preventing, reducing, alleviating or treating idiopathic vomiting

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- Number: US 10,441,623 B2
- Document ID: US10441623B2
- Status: Granted
- Kind: B2
- Application number: 14/198,662
- Filed: 2014-03-06
- Published: 2014-09-18
- Granted: 2019-10-15
- Earliest claimed: 2013-03-15
- Assignees: Mars, Incorporated
- Applicants: Mars, Incorporated
- Inventors: Jean Soon Park; Ping Hu; Yakang Lin; Lori Ann Reinsalu
- Web page: https://patentgrep.com/patent/US10441623B2

## CPC

- A61K 36/9066: Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
- A61K 36/00: Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines {(antigens from pollen A61K39/36)}
- A61K 36/15: Pinaceae (Pine family), e.g. pine or cedar
- A61K 36/16: Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
- A61K 36/185: Magnoliopsida (dicotyledons)
- A61K 36/19: Acanthaceae (Acanthus family)
- A61K 36/23: Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K 36/28: Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K 36/324: Boswellia, e.g. frankincense
- A61K 36/41: Crassulaceae (Stonecrop family)
- A61K 36/45: Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
- A61K 36/47: Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
- A61K 36/48: Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K 36/484: Glycyrrhiza (licorice)
- A61K 36/53: Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K 36/54: Lauraceae (Laurel family), e.g. cinnamon or sassafras
- A61K 36/55: Linaceae (Flax family), e.g. Linum
- A61K 36/61: Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
- A61K 36/634: Forsythia
- A61K 36/67: Piperaceae (Pepper family), e.g. Jamaican pepper or kava
- A61K 36/708: Rheum (rhubarb)
- A61K 36/718: Coptis (goldthread)
- A61K 36/736: Prunus, e.g. plum, cherry, peach, apricot or almond
- A61K 36/752: Citrus, e.g. lime, orange or lemon
- A61K 36/77: Sapindaceae (Soapberry family), e.g. lychee or soapberry
- A61K 36/81: Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K 36/82: Theaceae (Tea family), e.g. camellia
- A61K 36/835: Aquilaria
- A61K 36/87: Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
- A61K 36/88: Liliopsida (monocotyledons)
- A61K 36/889: Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
- A61K 36/9068: Zingiber, e.g. garden ginger
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 1/08: for nausea, cinetosis or vertigo; Antiemetics
- A61P 1/12: Antidiarrhoeals
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to compositions containing plant materials or extracts with inhibitory effect on a 5-HT3a and/or NK-1 receptor for preventing or treating idiopathic vomiting.

## Claims

### Claim 1

A method for treating idiopathic vomiting in a companion animal, comprising the step of orally administering to said companion animal one or more plant materials or extracts thereof in an effective amount for inhibiting a 5-hydroxytryptamine-3a serotonin (5-HT3a) receptor and/or a neurokinin-1 (NK-1) receptor, wherein the one or more plant materials or extracts thereof consists of Curcuma longa (turmeric) and licorice, ginger, rhubarb, or a combination thereof.

### Claim 2 (depends on 1)

The method of claim 1, wherein said plant materials or extracts are orally administered to the companion animal as a part of a dietary composition.

### Claim 3 (depends on 2)

The method of claim 2, wherein said dietary composition is a pet food comprising from 0.1 ppm to 75,000 ppm of said plant materials or extracts thereof, and wherein said pet food further comprises a source of carbohydrate, a source of protein, and optionally a source of fat.

### Claim 4 (depends on 2)

The method of claim 2, wherein said dietary composition is a pet food supplement comprising from 0.1% to 99% of said plant materials or extracts thereof by weight, and wherein the step of orally administering comprises feeding the pet food supplement to the companion animal either separately from or in combination with a pet food.

### Claim 5 (depends on 2)

The method of claim 2, wherein said dietary composition is orally administered to the companion animal at a frequency ranging from once a month to six times a day.

### Claim 6 (depends on 2)

The method of claim 2, wherein said dietary composition is orally administered to the companion animal for a duration ranging from five days to twenty five years.