# US 10,441,621 B2 · Flavonoid compositions and methods of use

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- Number: US 10,441,621 B2
- Document ID: US10441621B2
- Status: Granted
- Kind: B2
- Application number: 15/396,201
- Filed: 2016-12-30
- Published: 2017-04-20
- Granted: 2019-10-15
- Earliest claimed: 2015-09-23
- Assignees: Reoxcyn, LLC
- Applicants: Reoxcyn, LLC
- Inventors: Kurt Richards
- Web page: https://patentgrep.com/patent/US10441621B2

## CPC

- A61K 36/82: Theaceae (Tea family), e.g. camellia
- A61K 9/0056: {Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals}
- A61K 9/2018: {Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates}
- A61K 31/202: having three or more double bonds, e.g. linolenic (eicosanoids, e.g. leukotrienes A61K31/557)
- A61K 31/341: not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
- A61K 31/352: condensed with carbocyclic rings, e.g. methantheline {(cannabinoids A61K31/658)}
- A61K 31/353: 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K 31/375: Ascorbic acid, i.e. vitamin C; Salts thereof
- A61K 31/522: having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
- A61K 36/45: Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Flavonoid compositions containing the flavonoid quercetin and/or derivatives of quercetin are disclosed. The flavonoid compositions are formulated to improve the bioavailability of quercetin. Also provided herein are methods for improving athletic performance, improving cardiovascular health, and aiding in immune response and methods of improving athletic performance, improving bone health, preventing fatigue, reducing recovery time after exercise, countering oxidative stress, and/or boosting energy.

## Claims

### Claim 1

A method of increasing gut-derived phenolics in a subject, comprising:
administering a composition comprising bilberry fruit extract, green tea leaf extract, quercetin present in an amount of about 7.9% to about 16% (w/w), and omega 3 fatty acids to the subject.

### Claim 2 (depends on 1)

The method of claim 1, wherein the increased gut-derived phenolics are one or more of 1,2,3-benzenetriol sulfate, 3-methoxycatechol sulfate, 3-(3-hydroxyphenyl)propanoic acid sulfate, 3-hydroxyhippurate, or 4-methylcatechol sulfate.

### Claim 3 (depends on 1)

The method of claim 1, wherein the composition further comprises caffeine and vitamin C.

### Claim 4 (depends on 1)

The method of claim 1, wherein the omega 3 fatty acids comprises docosahexaenoic acid and eicosapentaenoic acid.

### Claim 5 (depends on 1)

The method of claim 1, wherein the composition further comprises a bioavailability enhancing agent selected from the group consisting of a solubilizing compound, a reducing compound, a stabilizing compound, a lubricating compound, an enteric coating, and a permeability enhancing compound.

### Claim 6 (depends on 1)

The method of claim 1, wherein the bilberry extract is present in an amount of 10-500 mg, the green tea leaf extract is present in an amount of 10-500 mg, the quercetin is present in an amount of 10-500 mg, and the omega 3 fatty acids is present in an amount of 10-500 mg.

### Claim 7 (depends on 1)

The method of claim 1, wherein the bilberry fruit extract comprises about 25% total anthocyanins.

### Claim 8 (depends on 1)

The method of claim 1, wherein the green tea leaf extract comprises about 50% epigallocatechin 3-gallate (EGCG).

### Claim 9 (depends on 2)

The method of claim 2, wherein the increased gut-derived phenolic 3-methoxycatechol sulfate is increased between 1-fold and 2 fold.

### Claim 10 (depends on 2)

The method of claim 2, wherein the increased gut-derived phenolic 3-(3-hydroxyphenyl)propanoic acid sulfate is increased between 0.5-fold and 1 fold.

### Claim 11 (depends on 2)

The method of claim 2, wherein the increased gut-derived 1,2,3-benzenetriol sulfate is increased between 1-fold and 2 fold.

### Claim 12 (depends on 1)

The method of claim 1, wherein the composition is administered to a subject at a dose of two tablets twice daily.

### Claim 13 (depends on 1)

The method of claim 1, wherein the composition is administered to a subject two to four times each day.

### Claim 14 (depends on 1)

The method of claim 1, wherein the gut-derived phenolics are gut-derived phenolic metabolites.

### Claim 15 (depends on 3)

The method of claim 3, wherein caffeine is present in an amount of 10-500 mg.

### Claim 16 (depends on 3)

The method of claim 3, wherein the vitamin C is present in an amount of 10-500 mg.

### Claim 17 (depends on 1)

The method of claim 1, wherein the composition further comprises one or more sugar, natural and artificial flavors, cellulose gum, sucralose, bamboo whole plant extract, guar gum, xanthan gum, citric acid, malic acid, or L-tartaric acid.

### Claim 18 (depends on 1)

The method of claim 1, wherein the composition is formulated as a chewable tablet.

### Claim 19 (depends on 1)

The method of claim 1, wherein the composition is administered to a subject prior to a meal.