# US 10,441,619 B2 · Longevity gene expression enhancer

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- Number: US 10,441,619 B2
- Document ID: US10441619B2
- Status: Granted
- Kind: B2
- Application number: 16/054,001
- Filed: 2018-08-03
- Published: 2018-12-06
- Granted: 2019-10-15
- Earliest claimed: 2014-08-01
- Assignees: Shiseido Company, Ltd.
- Applicants: Shiseido Company, Ltd.
- Inventors: Kaedeko Fukada; Tatsuya Hasegawa; Hiroshi Mori; Yoshiharu Suzuki
- Web page: https://patentgrep.com/patent/US10441619B2

## CPC

- A61K 36/23: Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K 2236/15: involving mechanical treatment, e.g. chopping up, cutting or grinding
- A61K 2236/17: involving drying, e.g. sun-drying or wilting
- A61K 2236/333: using mixed solvents, e.g. 70% EtOH
- A61K 2236/53: Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention provides a novel sirtuin-1 activating agent, and a formulation for suppressing cell senescence caused by oxidative stress, comprising the agent. In particular, the invention provides a sirtuin-1 activating agent consisting of a plant body or solvent extract of Peucedanum japonicum Thunb., and a formulation for suppressing cell senescence due to oxidative stress, comprising the agent.

## Claims

### Claim 1

A method for activating sirtuin-1 comprising topically administrating to a subject in need of activation of sirtuin-1 a dosage form containing an effective amount of a Peucedanum japonicum Thunb. plant body or solvent extract thereof.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the solvent extract is a water-containing ethanol extract.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the plant body of Peucedanum japonicum Thunb. is the leaves, stem or entire plant.

### Claim 4

A method for suppressing cell senescence due to oxidative stress comprising topically administrating to a subject in need of activation of sirtuin-1 a formulation comprising an effective amount of a Peucedanum japonicum Thunb. plant body or solvent extract thereof, wherein the cell senescence due to oxidative stress is suppressed via activation of sirtuin-1 in the subject.

### Claim 5 (depends on 4)

The method according to claim 4, wherein the solvent extract is a water-containing ethanol extract.

### Claim 6 (depends on 4)

The method according to claim 4, wherein the plant body of Peucedanum japonicum Thunb. is the leaves, stem or entire plant.