# US 10,441,612 B2 · Intestinal microbe therapy, composition therefor and method for preparing the same

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- Number: US 10,441,612 B2
- Document ID: US10441612B2
- Status: Granted
- Kind: B2
- Application number: 15/238,359
- Filed: 2016-08-16
- Published: 2018-02-22
- Granted: 2019-10-15
- Earliest claimed: 2016-08-16
- Assignees: Taichung Veterans General Hospital
- Applicants: Taichung Veterans General Hospital
- Inventors: Chun-Ying Wu
- Web page: https://patentgrep.com/patent/US10441612B2

## CPC

- A61K 35/74: Bacteria (therapeutic use of a bacterial protein A61K38/00)
- A61K 35/12: Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells (vaccines or medicinal preparations containing antigens or antibodies A61K39/00)
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- C12Q 1/689: for bacteria
- C12Q 2600/118: Prognosis of disease development
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES

## Abstract

The present invention discloses a method for treating and/or preventing metabolic syndrome and related diseases thereof, by administering a microbe composition to an individual to achieve the modulation of blood glucose, inhibition of body weight gain, reduction of low density cholesterol in blood, and reduction of hepatic expression of inflammatory factors, thereby effectively treating and/or preventing metabolic syndrome or related diseases thereof.

## Claims

### Claim 1

A method for treating and/or preventing obesity, regulating blood glucose, liver inflammation and reducing the level of low density cholesterol, comprising administering an effective amount of a composition to an individual to sufficiently increase the number of bacteria of at least one selected from the group consisting of genus Helicobacter and genus Odoribacter in the gastrointestinal tract of the individual to a level which treats and/or prevents obesity, regulating blood glucose, liver inflammation and reduces the level of low density cholesterol,
wherein the composition is prepared from feces, which is derived from a donor having an exercise habit, and
wherein the administration of the composition is via oral.

### Claim 2 (depends on 1)

The method of claim 1, wherein the exercise frequency of the donor is selected from the group consisting of at least two exercises per week at above 30 min per exercise, and an exercise at above 75 min per week.

### Claim 3 (depends on 1)

The method of claim 1, wherein the donor of the feces has a non-high-fat diet.

### Claim 4 (depends on 3)

The method of claim 3, wherein the proportion of fat in a daily diet of the donor is less than 77%.

### Claim 5

A method for treating and/or preventing obesity, regulating blood glucose, liver inflammation and reducing the level of low density cholesterol, comprising administering an effective amount of a composition to an individual to a level which treats and/or prevents obesity, regulating blood glucose, liver inflammation and reduces the level of low density cholesterol, the composition being derived from feces of a donor,
wherein the donor has at least one condition selected from the group consisting of an exercise habit and a non-high-fat diet habit, and
the administration of the composition is via oral.

### Claim 6 (depends on 5)

The method of claim 5, wherein the exercise habit means an exercise frequency selected from the group consisting of at least two exercises per week at above 30 min per exercise, or an exercise at above 75 min per week.

### Claim 7 (depends on 5)

The method of claim 5, wherein the non-high-fat diet means that the proportion of fat in a daily diet of the donor is less than 77%.

### Claim 8

A method for reducing body weight, comprising administering an effective amount of a composition to an individual to sufficiently reduce body weight, the composition being derived from feces of a donor, wherein:
the donor has at least one condition selected from the group consisting of an exercise habit and a non-high-fat diet habit, wherein the administration of the composition is via oral.

### Claim 9 (depends on 8)

The method of claim 8, wherein the exercise habit means an exercise frequency selected from the group consisting of at least two exercises per week at above 30 min per exercise, or an exercise at above 75 min per week.

### Claim 10 (depends on 8)

The method of claim 8, wherein the non-high-fat diet means that the proportion of fat in a daily diet of the donor is less than 77%.