# US 10,441,599 B2 · Pharmaceutical composition containing Ginkgolide B and blood platelet prostaglandin cyclooxygenase inhibitor and method for preparation thereof and use thereof

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,441,599 B2
- Document ID: US10441599B2
- Status: Granted
- Kind: B2
- Application number: 15/513,941
- Filed: 2015-09-25
- Published: 2017-09-28
- Granted: 2019-10-15
- Earliest claimed: 2014-09-26
- Assignees: Chengdu Baiyu Pharmaceutical Co., Ltd
- Applicants: Chengdu Baiyu Pharmaceutical Co., Ltd
- Inventors: Yi Sun
- Web page: https://patentgrep.com/patent/US10441599B2

## CPC

- A61K 31/616: by carboxylic acids, e.g. acetylsalicylic acid
- A61K 31/365: Lactones
- A61P 7/02: Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided is a pharmaceutical composition containing ginkgolide B and the blood platelet prostaglandin cyclooxygenase inhibitor aspirin, a method for preparation of the pharmaceutical composition and a use thereof. When used together, ginkgolide B and aspirin have a synergistic effect in resisting platelet aggregation.

## Claims

### Claim 1

A pharmaceutical composition comprising:
Ginkgolide B in an amount of 10 parts by weight, and
Aspirin in an amount of 200 parts by weight.

### Claim 2 (depends on 1)

A method for preparing the pharmaceutical composition of claim 1, comprising:
weighing out 10 parts by weight of the Ginkgolide B and 200 parts by weight of the Aspirin;
mixing the Ginkgolide B and the Aspirin, and
adding a pharmaceutically acceptable auxiliary to prepare the pharmaceutical composition.

### Claim 3

A method for inhibiting platelet aggregation, comprising:
administering a pharmaceutical composition to a subject requiring platelet aggregation inhibition, the pharmaceutical composition comprising:
Ginkgolide B in an amount of 10 parts by weight, and
Aspirin in an amount of 200 parts by weight.