# US 10,441,590 B2 · Methods for treating pulmonary hypertension

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- Number: US 10,441,590 B2
- Document ID: US10441590B2
- Status: Granted
- Kind: B2
- Application number: 15/643,630
- Filed: 2017-07-07
- Published: 2018-05-10
- Granted: 2019-10-15
- Earliest claimed: 2015-01-12
- Assignees: Reviva Pharmaceuticals, Inc.
- Applicants: Reviva Pharmaceuticals, Inc.
- Inventors: Laxminarayan Bhat; Marc Cantillon; Ellen M. Wallis; Seema Rani Bhat
- Web page: https://patentgrep.com/patent/US10441590B2

## CPC

- A61K 31/538: ortho- or peri-condensed with carbocyclic ring systems
- A61P 9/12: Antihypertensives
- A61P 25/22: Anxiolytics
- A61P 25/24: Antidepressants
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention provides a method of using arylpiperazine derivatives for treating pulmonary hypertension. The method comprises a step of administering to a patient in need thereof an effective amount of a compound of Formula 1, which is an arylpiperazine derivative.

## Claims

### Claim 1

A method of treating pulmonary hypertension in a subject, the method comprising administering to a subject suffering from pulmonary hypertension an effective amount of a compound of:
or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the compound is in the form of a hydrochloride salt.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the compound is administered in a pharmaceutical composition comprising a pharmaceutically acceptable carrier, excipient, or diluent.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the compound is orally administered.

### Claim 5 (depends on 1)

The method according to claim 1, which treats pulmonary arterial hypertension.

### Claim 6 (depends on 1)

The method according to claim 1, which treats pulmonary hypertension in a subject with chronic obstructive pulmonary disease (COPD).

### Claim 7 (depends on 1)

The method according to claim 1, which treats pulmonary hypertension in a subject with sickle cell disease.

### Claim 8 (depends on 1)

The method according to claim 1, which treats pulmonary hypertension in a subject with human immunodeficiency virus (HIV).

### Claim 9 (depends on 1)

The method according to claim 1, which further treats depression in the subject.

### Claim 10 (depends on 1)

The method according to claim 1, which further treats anxiety in the subject.