# US 10,441,557 B2 · Germicidal compositions comprising carboxylic acid mixture and use as topical disinfectants

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- Number: US 10,441,557 B2
- Document ID: US10441557B2
- Status: Granted
- Kind: B2
- Application number: 14/653,174
- Filed: 2013-12-20
- Published: 2015-11-26
- Granted: 2019-10-15
- Earliest claimed: 2012-12-21
- Assignees: DeLaval Holding AB
- Applicants: DeLaval Holding AB
- Inventors: Maria Buchalova; Alex Skender
- Web page: https://patentgrep.com/patent/US10441557B2

## CPC

- A61K 31/194: having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
- A01N 37/02: Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
- A61K 9/0017: {Non-human animal skin, e.g. pour-on, spot-on}
- A61K 31/185: Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids (hydroxamic acids A61K31/16; peroxy acids A61K31/327)
- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K 47/20: containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
- A61P 31/04: Antibacterial agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Germicidal compositions and methods of using the same in the prevention and treatment of various hoof diseases are provided. The germicidal compositions generally comprise formic acid, at least one C2-C10 carboxylic acid, and one or more anionic surfactants, such as an α-olefin sulfonate. The germicidal compositions may be applied topically to the hooves of an animal through various means including the use of footbaths.

## Claims

### Claim 1

An aqueous germicidal composition comprising:
between 0.05% to 25% by weight of formic acid;
one or more C2-C10 carboxylic acids; and
two or more anionic surfactants, wherein an α-olefin sulfonate comprises at least 50% by weight of said anionic surfactants.

### Claim 2 (depends on 1)

The composition according to claim 1, wherein said composition comprises between about 0.05% to about 35% by weight of said C2-C10 carboxylic acid.

### Claim 3 (depends on 1)

The composition according to claim 1, wherein said one or more C2-C10 carboxylic acids are selected from the group consisting of acetic acid, lactic acid, citric acid, propionic acid, butyric acid, glycolic acid, gluconic acid, glutaric acid, adipic acid, aspartic acid, glutamic acid, tartaric acid, pyruvic acid, fumaric acid, sorbic acid, maleic acid, malic acid, caprylic acid, perlagonic acid, and capric acid.

### Claim 4 (depends on 1)

The composition according to claim 1 wherein said α-olefin sulfonate surfactant is a sodium C8-C18 α-olefin sulfonate.

### Claim 5 (depends on 1)

The composition according to claim 1, wherein said two or more anionic surfactants are present in said composition at a level of between about 0.1% to about 60% by weight.

### Claim 6 (depends on 1)

The composition according to claim 1, wherein said composition has a pH of less than 5.

### Claim 7 (depends on 1)

The composition according to claim 1, wherein said composition further comprises a non-ionic surfactant.

### Claim 8 (depends on 7)

The composition according to claim 7, wherein said non-ionic surfactant comprises an alcohol ethoxylate.

### Claim 9 (depends on 1)

The composition according to claim 1, wherein said composition further comprises one or more members selected from the group consisting of pH adjusting agents, wetting agent, foaming agents, dyes, viscosity control agents, preservatives, skin conditioners, coupling agents, and solvents.

### Claim 10 (depends on 1)

The composition according to claim 1, wherein said composition further comprises one or more germicides selected from the group consisting of N,N-bis(3-aminopropyl) C6-C18 alkyl amines, bronopol, chlorhexidine salts, triclosan, glycolic acid, polyhexamethyl biguanide, polyhexamethylene guanidine hydrochloride, polyhexamethylene guanidine hydrophosphate, poly[2-(2-ethoxy)-ethoxyethyl]-guanidinium chloride, benzyl alcohol, and benzoic acid.

### Claim 11 (depends on 1)

The composition according to claim 1, wherein said composition comprises a homogeneous solution that remains physical stable for extended storage periods of at least 3 months at 25° C.

### Claim 12 (depends on 1)

A germicidal use solution for treatment or prevention of hoof diseases comprising 1 part by weight of the aqueous composition according to claim 1 diluted with between about 1 to about 100 parts by weight water.

### Claim 13 (depends on 12)

The use solution of claim 12, wherein said use solution remains physically stable upon exposure to a temperature of 10° C. for 24 hours, or in the presence of 3 g/L bovine albumin solution.

### Claim 14

An aqueous germicidal composition comprising:
between 0.05% to 25% by weight of formic acid;
between about 0.05% to about 35% by weight of one or more carboxylic acids selected from the group consisting of acetic acid, lactic acid, and citric acid; and
two or more anionic surfactants, wherein an α-olefin sulfonate comprises at least 50% by weight of said anionic surfactants,
wherein upon testing under AOAC 960.09 standards at 10° C., 1 minute contact time, and in the presence of 10% manure, the composition exhibits at least a 5-log reduction in Escherichia coli and Staphylococcus aureus.

### Claim 15 (depends on 1)

A method for treating or preventing infectious hoof diseases comprising topically administering a therapeutically effective amount of a composition according to claim 1 to the hooves of an animal.

### Claim 16 (depends on 15)

The method according to claim 15, wherein said animal hooves have not undergone a pre-washing step prior to administration of said composition thereto.

### Claim 17 (depends on 15)

The method according to claim 15, wherein said animal hooves, prior to administration of said composition thereto, include organic soils thereon.

### Claim 18 (depends on 17)

The method according to claim 17, wherein said organic soils comprise manure.

### Claim 19 (depends on 15)

The method according to claim 15, wherein said composition is diluted with water to form a use solution prior to administration to said animal hooves.

### Claim 20 (depends on 15)

The method according to claim 15, wherein the hoof disease is selected from papillomatous digital dermatitis, interdigital phlegmon, interdigital dermatitis, laminitis, white line disease, and heel erosion.

### Claim 21 (depends on 15)

The method according to claim 15, wherein said composition is administered as one of a spray, a foam, a gel, an ointment, a cream, a footbath or a footwrap.