# US 10,441,551 B2 · Patch > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,441,551 B2 - Document ID: US10441551B2 - Status: Granted - Kind: B2 - Application number: 15/769,393 - Filed: 2016-10-24 - Published: 2018-10-11 - Granted: 2019-10-15 - Earliest claimed: 2015-10-26 - Assignees: Hisamitsu Pharmaceutical Co., Inc. - Applicants: Hisamitsu Pharmaceutical Co., Inc. - Inventors: Atsushi Sonobe; Akio Takeuchi; Yasunori Takada - Web page: https://patentgrep.com/patent/US10441551B2 ## CPC - A61K 9/7053: {obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene} - A61K 9/70: Web, sheet or filament bases {; Films; Fibres of the matrix type containing drug (hollow drug-filled fibres A61K9/0092)} - A61K 9/703: {characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches} - A61K 9/7069: {obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide} - A61K 31/4468: having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl - A61K 47/02: Inorganic compounds - A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers - A61K 47/14: Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters - A61K 47/20: containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids - A61K 47/22: Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones - A61K 47/32: Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} - A61K 47/44: Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin (synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14) - A61P 25/04: Centrally acting analgesics, e.g. opioids - A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract A patch comprises a backing and an adhesive layer laminated on at least one surface of the backing, in which the adhesive layer contains at least one selected from the group consisting of fentanyl and salts thereof, and contains an adhesive base material and an antioxidant having a sulfur atom in its molecule. ## Claims ### Claim 1 A patch comprising a backing, and an adhesive layer laminated on at least one surface of the backing, wherein the adhesive layer contains at least one selected from the group consisting of fentanyl and salts thereof, and contains an adhesive base material and an antioxidant having a sulfur atom in its molecule, said antioxidant being at least one selected from the group consisting of 2-mercaptobenzimidazole and sodium metabisulfite. ### Claim 2 (depends on 1) The patch according to claim 1, wherein the adhesive base material is a rubber-based adhesive base material. ### Claim 3 (depends on 1) The patch according to claim 1, wherein a content of the fentanyl and the salts thereof is 0.05 to 20% by mass relative to a total mass of the adhesive layer, a content of the adhesive base material is 0.1 to 98% by mass relative to the total mass of the adhesive layer in terms of solid content, and a content of the antioxidant having a sulfur atom in its molecule is 0.01 to 5% by mass relative to the total mass of the adhesive layer. ### Claim 4 (depends on 1) The patch according to claim 1, wherein the adhesive layer further contains a fatty acid ester as an absorption enhancer. ### Claim 5 (depends on 4) The patch according to claim 4, wherein a content of the absorption enhancer is 0.01 to 20% by mass relative to the total mass of the adhesive layer. ### Claim 6 (depends on 1) The patch according to claim 1, wherein the adhesive layer further contains a phenolic antioxidant. ### Claim 7 (depends on 6) The patch according to claim 6, wherein a content of the phenolic antioxidant is 0.01 to 5% by mass relative to the total mass of the adhesive layer. ### Claim 8 (depends on 1) The patch according to claim 1, wherein the adhesive layer further contains, as a desalting agent, at least one selected from the group consisting of basic alkaline metal salts, alkaline earth metal salts, alkali metal hydroxides, alkali earth metal hydroxides and low-molecular weight compounds containing basic nitrogen, and a content of the desalting agent is 0.01 to 15% by mass relative to the total mass of the adhesive layer. ### Claim 9 (depends on 1) The patch according to claim 1, wherein the adhesive layer further contains, as a tackifier, at least one selected from the group consisting of alicyclic saturated hydrocarbon resins, terpene resins, rosin resins, rosin ester resins, and oil-soluble phenolic resins, and a content of the tackifier is 0.1 to 70% by mass relative to the total mass of the adhesive layer. ### Claim 10 (depends on 1) The patch according to claim 1, wherein the adhesive layer further contains, as a softener, at least one selected from the group consisting of liquid paraffin, squalane, olive oil, camellia oil, persic oil, and arachis oil, and a content of the softener is 1 to 70% by mass relative to the total mass of the adhesive layer.