# US 10,441,545 B2 · Microcellular microstructure and method for manufacturing same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,441,545 B2 - Document ID: US10441545B2 - Status: Granted - Kind: B2 - Application number: 15/536,586 - Filed: 2015-12-16 - Published: 2017-12-14 - Granted: 2019-10-15 - Earliest claimed: 2014-12-16 - Assignees: Juvic Inc. - Applicants: Industry-Academic Cooperation Foundation, Yonsei University - Inventors: Hyung Il Jung; Su Yong Kim; Hui Suk Yang - Web page: https://patentgrep.com/patent/US10441545B2 ## CPC - A61K 9/5005: {Wall or coating material} - A61K 9/0021: {Intradermal administration, e.g. through microneedle arrays or needleless injectors} - A61K 9/5089: {Processes} - A61M 37/00: Other apparatus for introducing media into the body (for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30); Percutany, i.e. introducing medicines into the body by diffusion through the skin (salt baths A61H33/04) - A61M 37/0015: {by using microneedles} - A61P 17/00: Drugs for dermatological disorders - A61M 31/002: {Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time (artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50)} - A61M 2037/0053: {Methods for producing microneedles} - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract The present invention relates to a microcontainer microstructure including a microcontainer film structure having a sharp tip portion and a method of manufacturing the same. ## Claims ### Claim 1 A microcontainer microstructure comprising: a substrate provided with a hole having an upper opening and a lower opening; and a microcontainer film structure formed in contact with an inner surface of the hole and comprising a container portion having a volume of 100um3 to 1,000,000 um3 and a sharp tip portion, wherein the container portion is loaded with a drug, wherein the container portion and the sharp tip portion of the microcontainer film structure are both configured to be inserted into a human body, and wherein the substrate is configured to contact a surface of the human body but not be inserted into the human body. ### Claim 2 (depends on 1) The microcontainer microstructure of claim 1, wherein the sharp tip portion is a polymer composition in contact with the microcontainer. ### Claim 3 (depends on 1) The microcontainer microstructure of claim 1, wherein the microcontainer microstructure comprises a second film structure formed in combination with the microcontainer film structure, to seal the drug. ### Claim 4 (depends on 3) The microcontainer microstructure of claim 3, wherein the microcontainer film structure and the second film structure are formed in an integrated form. ### Claim 5 A method of manufacturing a microcontainer microstructure, the method comprising: (a) preparing a substrate provided with a hole having an upper opening and a lower opening; and (b) preparing a microcontainer film structure formed in contact with an inner surface of the hole and comprising a container portion having a volume of 100 um3 to 1,000,000 um3 and a sharp tip portion; and (c) loading a drug into the container portion, wherein the container portion and the sharp tip portion of the microcontainer film structure are both configured to be inserted into a human body, and wherein the substrate is configured to contact a surface of the human body but not be inserted into the human body. ### Claim 6 (depends on 5) The method of claim 5, further comprising, prior to process (b), filling the hole with a polymer composition or a thermoplastic polymer powder. ### Claim 7 (depends on 6) The method of claim 6, wherein, when the filling is performed using the polymer composition, in process (b) above, the preparing of the microcontainer film structure is performed by removing a solvent of the polymer composition. ### Claim 8 (depends on 6) The method of claim 6, wherein, when the filling is performed using the thermoplastic polymer powder, in process (b) above, the preparing of the microcontainer film structure is performed by plasticizing the thermoplastic polymer powder by heat and then curing the plasticized thermoplastic polymer powder. ### Claim 9 (depends on 5) The method of claim 5, wherein, in process (b), the sharp tip portion is formed by applying an outward force to a polymer composition formed on an upper portion of the microcontainer film structure, or is formed by additionally attaching a separate microstructure to an upper portion of the microcontainer film structure. ### Claim 10 (depends on 5) The method of claim 5, wherein the drug is sealed by a second film structure.