# US 10,441,523 B2 · Regimen for controlling or reducing dentine hypersensitivity > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,441,523 B2 - Document ID: US10441523B2 - Status: Granted - Kind: B2 - Application number: 15/161,160 - Filed: 2016-05-20 - Published: 2016-09-15 - Granted: 2019-10-15 - Earliest claimed: 2016-05-20 - Assignees: The Procter & Gamble Company - Applicants: The Procter & Gamble Company - Inventors: Ross Strand; Alastair Robert Edward MacGregor; Claire Goodall - Web page: https://patentgrep.com/patent/US10441523B2 ## CPC - A61K 8/556: {Derivatives containing from 2 to 10 oxyalkylene groups} - A61K 8/21: Fluorides; Derivatives thereof - A61K 8/24: Phosphorous; Compounds thereof - A61K 8/55: Phosphorus compounds - A61K 31/6615: Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid - A61K 33/42: Phosphorus; Compounds thereof - A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis - A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses - A61K 2800/884: Sequential application - A61K 2800/92: Oral administration - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract The present invention provides a method of treating a tooth surface to control or reduce dentine hypersensitivity, comprising the steps: (a) contacting the tooth surface with a first composition comprising an organophosphate; and thereafter (b) contacting the tooth surface with a second composition comprising a water-insoluble calcium phosphate. ## Claims ### Claim 1 A method of treating a tooth surface comprising the steps: (a) contacting the tooth surface by contacting the tooth surface with a first composition comprising an organophosphate having the formula: wherein R is a hydrocarbyl comprising 4 to 22 carbon atoms; X and Y are each independently an alkylene comprising 2 to 4 carbon atoms; a and b are each independently an integer selected from 0 to 20, and a+b is in the range from 0 to 20; Z1and Z2 are each independently selected from hydrogen, hydrocarbyl comprising 1 to 26 carbons, and a counter ion, provided that at least one of Z1 and Z2 is hydrogen or a counter ion; and thereafter (b)occluding tubules exposed on the tooth surface by contacting the tooth surface with a second composition comprising a water-insoluble calcium phosphate, wherein the water-insoluble calcium phosphate has a calcium to phosphorus molar ratio from 1:1 to 10:1. ### Claim 2 (depends on 1) The method of claim 1, wherein contacting step (b) is initiated within 15 minutes after the conclusion of contacting step (a). ### Claim 3 (depends on 2) The method of claim 2, wherein R is an alkyl comprising 8 to 16 carbon atoms; a+b is from 1 to 10; and Z1 and Z2 are each independently selected from the group consisting of hydrogen and an alkali metal counter ion. ### Claim 4 (depends on 3) The method of claim 3, wherein at least one of Z1 and Z2 is an alkali metal counter ion selected from the group consisting of sodium ion and potassium ion; and wherein the first composition comprises 0.01% to 10%, by weight, of the organophosphate. ### Claim 5 (depends on 4) The method of claim 4, wherein the organophosphate is selected from the group consisting of sodium laureth-1 phosphate, sodium laureth-2 phosphate, sodium laureth-3 phosphate, sodium laureth-4 phosphate, potassium laureth-1 phosphate, sodium laureth-9 phosphate, sodium myreth-2 phosphate, sodium pareth-1 phosphate, and mixtures thereof. ### Claim 6 (depends on 5) The method of claim 5, wherein the first composition comprises 0.05% to 5%, by weight, of sodium laureth-1 phosphate. ### Claim 7 (depends on 2) The method of claim 2, wherein the second composition further comprises a water-soluble fluoride source. ### Claim 8 (depends on 7) The method of claim 7, wherein the water-soluble fluoride source is selected from the group consisting of sodium fluoride, stannous fluoride, sodium monofluorophosphate, amine fluoride, and mixtures thereof; and wherein the first composition comprises 0.01% to 10%, by weight, of sodium laureth-1 phosphate. ### Claim 9 (depends on 2) The method of claim 2, wherein the water-insoluble calcium phosphate is selected from the group consisting of apatite, calcium halide phosphate, dicalcium phosphate, tricalcium phosphate, octacalcium phosphate, and mixtures thereof. ### Claim 10 (depends on 9) The method of claim 9, wherein the second composition comprises 0.1% to 20%, by weight, of apatite. ### Claim 11 (depends on 10) The method of claim 10, wherein the second composition comprises 1% to 5%, by weight, of hydroxyapatite. ### Claim 12 (depends on 2) The method of claim 2, wherein the first composition is a toothpaste composition and the second composition is a mouth rinse. ### Claim 13 (depends on 2) The method of claim 2, wherein the first composition and the second composition are each a mouth rinse. ### Claim 14 (depends on 2) The method of claim 2, wherein the second composition is a mouth rinse, with a viscosity from 2000 cps to 8000 cps. ### Claim 15 (depends on 2) The method of claim 2, wherein the first composition has a pH from 6 to 8. ### Claim 16 (depends on 2) The method of claim 2, wherein the second composition has a pH from 7 to 10. ### Claim 17 (depends on 2) The method of claim 2, wherein contacting steps (a) and (b) each independently has a contacting duration from 5 seconds to 5 minutes; and contacting step (b) is initiated immediately after the conclusion of contacting step (a). ### Claim 18 (depends on 17) The method of claim 17, wherein the first composition is a mouth rinse comprising 0.05% to 5%, by weight, of sodium laureth-1 phosphate and 0.01% to 1%, by weight, of a sodium fluoride, and the second composition is a mouth rinse comprising 1% to 5%, by weight, of hydroxyapatite; and wherein the second composition has a pH from 7 to 9 and a viscosity from 2000 cps to 8000 cps.