# US 10,441,517 B2 · Oral care composition

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- Number: US 10,441,517 B2
- Document ID: US10441517B2
- Status: Granted
- Kind: B2
- Application number: 15/106,457
- Filed: 2014-12-10
- Published: 2016-11-24
- Granted: 2019-10-15
- Earliest claimed: 2013-12-19
- Assignees: Colgate-Palmolive Company
- Applicants: Colgate-Palmolive Company
- Inventors: Michael Prencipe; Yun Xu; Xiao Yi Huang
- Web page: https://patentgrep.com/patent/US10441517B2

## CPC

- A61K 8/27: Zinc; Compounds thereof
- A61K 8/43: Guanidines
- A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K 2800/51: Chelating agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

An oral care composition comprising: (a) arginine, in free or salt form; and (b) zinc oxide and zinc citrate. The oral care composition can reduce or inhibit biofilm formation in an oral cavity.

## Claims

### Claim 1

An oral care composition comprising:
a. arginine, in free or salt form; and
b. zinc oxide and zinc citrate,
wherein a molar ratio of arginine to total zinc salts is 0.4:1 to 0.8:1 and wherein a weight ratio of zinc oxide to zinc citrate is 1.7:1 to 2.3:1 and wherein the arginine is present in an amount of 1.4 weight % to 1.6 weight % based on the total weight of the composition.

### Claim 2 (depends on 1)

The oral care composition of claim 1, wherein the arginine is present in an amount of about 1.5 weight %, based on the total weight of the composition.

### Claim 3 (depends on 1)

The oral care composition of claim 1, wherein the total concentration of zinc salts in the composition is 0.2 weight % to 5 weight %, based on the total weight of the composition.

### Claim 4 (depends on 1)

The oral care composition of claim 1, wherein the composition comprises zinc oxide in an amount of 0.5 weight % to 1.5 weight % and zinc citrate in an amount of 0.25 weight % to 0.75 weight %, based on the total weight of the composition.

### Claim 5 (depends on 4)

The oral care composition of claim 4, wherein the composition comprises zinc oxide in an amount of about 1 weight % and zinc citrate in an amount of about 0.5 weight %, based on the total weight of the composition.

### Claim 6 (depends on 4)

The oral care composition of claim 4, wherein the weight ratio of zinc oxide to zinc citrate is 1.9:1 to 2.1:1, or about 2:1.

### Claim 7 (depends on 1)

An oral care composition of claim 1, for use in reducing or inhibiting biofilm formation in an oral cavity.

### Claim 8 (depends on 1)

A method of reducing or inhibiting biofilm formation in an oral cavity, the method comprising contacting the oral cavity with an oral care composition of claim 1.

### Claim 9 (depends on 8)

The method of claim 8, wherein the arginine is present in the oral care composition in an amount of about 1.5 weight %, based on the total weight of the composition.

### Claim 10 (depends on 8)

The method of claim 8, wherein the total concentration of zinc salts in the oral care composition is 0.2 weight % to 5 weight %, based on the total weight of the composition.

### Claim 11 (depends on 8)

The method of claim 8, wherein the zinc oxide is present in the oral care composition in an amount of 0.5 weight % to 1.5 weight % and the zinc citrate is present in the oral care composition in an amount of 0.25 weight % to 0.75 weight %, based on the total weight of the composition.

### Claim 12 (depends on 11)

The method of claim 11, wherein the zinc oxide is present in the oral care composition in an amount of about 1 weight % and the zinc citrate is present in the oral care composition in an amount of about 0.5 weight %, based on the total weight of the composition.

### Claim 13 (depends on 1)

The oral care composition of claim 1, wherein the molar ratio of arginine to total zinc salts is about 0.65:1 and wherein the weight ratio of zinc oxide to zinc citrate is about 2:1.