# US 10,441,516 B2 · Oral care composition > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,441,516 B2 - Document ID: US10441516B2 - Status: Granted - Kind: B2 - Application number: 15/068,418 - Filed: 2016-03-11 - Published: 2016-07-07 - Granted: 2019-10-15 - Earliest claimed: 2016-03-11 - Assignees: Colgate-Palmolive Company - Applicants: Colgate-Palmolive Company - Inventors: Venda Porter; Andre Morgan; Michael Prencipe; Sarita Mello - Web page: https://patentgrep.com/patent/US10441516B2 ## CPC - A61K 8/27: Zinc; Compounds thereof - A61K 8/0241: {Containing particulates characterized by their shape and/or structure (see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes)} - A61K 8/11: Encapsulated compositions - A61K 8/21: Fluorides; Derivatives thereof - A61K 8/25: Silicon; Compounds thereof - A61K 8/731: {Cellulose; Quaternized cellulose derivatives} - A61K 8/86: Polyethers - A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis - A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses - A61K 2800/412: Microsized, i.e. having sizes between 0.1 and 100 microns - A61K 2800/56: Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms - A61K 2800/624: by macromolecular compounds - A61K 2800/651: The particulate/core comprising inorganic material - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract Disclosed are oral care compositions, for example dentifrice compositions, comprising an orally acceptable vehicle, metal oxide particles having an average particle size of no greater than a dentin tubule and a polymeric adherent material for adhering the metal oxide particles in the dentin tubule. The metal oxide particles have a median particle size of 5 microns or less, and may comprise zinc oxide. ## Claims ### Claim 1 An oral care composition comprising an orally acceptable vehicle selected from glycerin, sorbitol, propylene glycol and polyethylene glycol; metal oxide particles comprising zinc oxide; and a polymeric adherent material comprising: at least one of hydroxypropylmethyl cellulose (HPMC), hydroxyethylpropyl cellulose (HEPC), hydroxybutylmethyl cellulose (HBMC), carboxymethyl cellulose (CMC) or combinations thereof, and at least one of poly (ethylene oxide) polymers, linear polyvinylpyrrolidone (PVP) and cross-linked polyvinylpyrrolidone (PVP), polyethylene glycol (PEG)/polypropylene glycol (PPG) copolymer, ethylene oxide (EO)-propylene oxide (PO) block copolymers, ester gum, shellac, pressure sensitive silicone adhesives, methacrylates, poly(methyl vinyl ether/maleic anhydride) and poly(methyl vinyl ether/maleic acid) or combinations thereof, wherein the metal oxide particles are encapsulated in the polymeric adherent material. ### Claim 2 (depends on 1) The oral care composition according to claim 1, wherein the polymeric adherent material comprises carboxymethyl cellulose, and at least one of linear polyvinylpyrrolidone, cross-linked polyvinylpyrrolidone, poly(methyl vinyl ether/maleic anhydride) and poly(methyl vinyl ether/maleic acid), or combinations thereof. ### Claim 3 (depends on 1) The oral care composition according to claim 1, wherein the vehicle comprises polyethylene glycol. ### Claim 4 (depends on 1) The oral care composition according to claim 1, further comprising a fluoride ion source. ### Claim 5 (depends on 4) The oral care composition according to claim 4, wherein the fluoride ion source comprises sodium fluoride, ammonium fluoride, monofluorophosphates, stannous fluoride, indium fluoride, amine fluorides or combinations thereof. ### Claim 6 (depends on 5) The oral care composition according to claim 5, wherein the fluoride ion source comprises stannous fluoride. ### Claim 7 (depends on 4) The oral care composition according to claim 4, wherein the composition further comprises a fluoride ion source comprising stannous fluoride. ### Claim 8 (depends on 1) The oral care composition according to claim 1 wherein the metal oxide particles have an average particle size from 1 to 7 microns. ### Claim 9 (depends on 1) The oral care composition according to claim 1 wherein the metal oxide particles are present in an amount of up to 5% by weight, based on the total weight of the oral care composition. ### Claim 10 (depends on 9) The oral care composition according to claim 9 wherein the metal oxide particles are present in an amount of from 0.5 to 2% by weight, being based on the total weight of the oral care composition. ### Claim 11 (depends on 1) The oral care composition according to claim 1, further comprising silica particles having an average particle size of 8 microns or less. ### Claim 12 (depends on 11) The oral care composition according to claim 11 wherein the silica particles are present in an amount of up to 10% by weight, based on the total weight of the oral care composition. ### Claim 13 (depends on 1) The oral care composition according to claim 1 which is a dentifrice composition. ### Claim 14 (depends on 13) The oral care composition according to claim 13, which is a toothpaste or a gel. ### Claim 15 (depends on 1) The oral care composition according to claim 1, wherein the composition is formulated into a form selected from a mouth rinse, a gum, a dissolvable lozenge, and a dissolvable film. ### Claim 16 (depends on 1) A method of occluding a dentin tubule within the surface of a mammalian tooth comprising applying to the surface of a mammalian tooth an oral care composition of claim 1. ### Claim 17 (depends on 1) A method of protecting dental surfaces from acid-mediated degradation, comprising applying to the surface of a mammalian tooth an oral care composition of claim 1.