# US 10,441,513 B2 · Oral delivery system

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- Number: US 10,441,513 B2
- Document ID: US10441513B2
- Status: Granted
- Kind: B2
- Application number: 15/786,938
- Filed: 2017-10-18
- Published: 2018-04-05
- Granted: 2019-10-15
- Earliest claimed: 2014-04-22
- Applicants: Christian Arnold; Armin Armani
- Inventors: Christian Arnold; Armin Armani
- Web page: https://patentgrep.com/patent/US10441513B2

## CPC

- A61K 8/0204: {Specific forms not provided for by any of groups A61K8/0208 - A61K8/14}
- A61K 8/0216: {Solid or semisolid forms}
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61K 8/65: Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
- A61K 8/66: Enzymes
- A61K 8/731: {Cellulose; Quaternized cellulose derivatives}
- A61K 8/732: {Starch; Amylose; Amylopectin; Derivatives thereof}
- A61K 8/8147: {Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers}
- A61K 8/8152: {Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers}
- A61K 8/8158: {Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers}
- A61K 8/817: {Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)}
- A61K 8/8176: {Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers}
- A61K 8/84: obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K 8/85: Polyesters
- A61K 8/86: Polyethers
- A61K 9/0063: {Periodont}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 31/785: Polymers containing nitrogen
- A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 31/02: Local antiseptics
- A61P 31/04: Antibacterial agents
- A61P 31/10: Antimycotics
- A61P 31/12: Antivirals
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present invention provides a delivery system for the treatment and/or prevention of infectious pathological changes, including compositions comprising polyhexanide, various pharmaceutical formulations, and processes for using these formulations in oral treatment modalities.

## Claims

### Claim 1

A chewing gum comprising an antibacterial agent in an amount effective to treat infectious pathological changes in the mouth and throat, wherein the antibacterial agent is the only antibacterial agent in the chewing gum and wherein the antibacterial agent consists of polyhexanide and optional fluoride.

### Claim 2 (depends on 1)

The gum of claim 1, wherein the gum further comprises at least one suspending agent or humectant selected from the group consisting of water, glycerin, propylene glycol, sorbitol syrup, and combinations thereof.

### Claim 3 (depends on 1)

The gum of claim 1, wherein the gum further comprises at least one thickening agent, stabilizer, or binder.

### Claim 4 (depends on 3)

The gum of claim 3, wherein the at least one thickening agent, stabilizer, or binder is selected from the group consisting of a gel, a starch, an alginate, an oil, a cellulose gum, and combinations thereof.

### Claim 5 (depends on 1)

The gum of claim 1, wherein the gum further comprises a gum base selected from the group consisting of chicle, gutta-percha, latex, benzoin resin, and gum arabic.

### Claim 6 (depends on 1)

The gum of claim 1, wherein the gum comprises a synthetic thermoplastic gum base.

### Claim 7 (depends on 6)

The gum of claim 6, wherein the synthetic thermoplastic is selected from the group consisting of polyvinyl acetate, polybutadiene styrene, polyisobutylene, isoprene, polyvinyl ether, and polyethylene.

### Claim 8 (depends on 1)

The gum of claim 1, wherein the gum comprises a filler selected from the group consisting of magnesium stearate, chalk, calcium carbonate, a silicate, and a cellulose.

### Claim 9 (depends on 1)

The gum of claim 1, wherein the gum comprises at least one aromatic substance, sweetener, or sugar substitute.

### Claim 10 (depends on 9)

The gum of claim 9, wherein the at least one aromatic substance, sweetener, or sugar substitute is selected from the group consisting of menthol, peppermint oil, sodium saccharin, aspartame, acesulfame, sorbitol, maltitol, xylitol, fructose, and combinations thereof.

### Claim 11 (depends on 1)

The gum of claim 1, wherein the gum comprises an emulsifier, a resin, a wax, or glucitol.

### Claim 12 (depends on 1)

The gum of claim 1, wherein the gum comprises an abrasive selected from the group consisting of calcium carbonate, calcium phosphate, a metaphosphate, silicic acid, an aluminum oxide, a silicate, talcum, and combinations thereof.

### Claim 13 (depends on 1)

The gum of claim 1, wherein fluoride is present in the antibacterial agent.