# US 10,441,445 B2 · Radiopaque intraluminal stents comprising cobalt-based alloys containing one or more platinum group metals, refractory metals, or combinations thereof > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,441,445 B2 - Document ID: US10441445B2 - Status: Granted - Kind: B2 - Application number: 15/429,339 - Filed: 2017-02-10 - Published: 2017-10-19 - Granted: 2019-10-15 - Earliest claimed: 2010-11-17 - Assignees: Abbott Cardiovascular Systems Inc. - Applicants: Abbott Cardiovascular Systems, Inc. - Inventors: Pamela A. Kramer-Brown; Kayla L. Calvert; John A. Simpson; Stephen D. Pacetti; Austin M. Leach - Web page: https://patentgrep.com/patent/US10441445B2 ## CPC - A61F 2/82: Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07) - A61F 2/06: Blood vessels - A61L 31/022: {Metals or alloys} - A61L 31/18: Materials at least partially X-ray or laser opaque - C22C 19/07: based on cobalt - A61F 2250/0098: radio-opaque, e.g. radio-opaque markers - C22C 19/05: with chromium - C22C 27/00: Alloys based on rhenium or a refractory metal not mentioned in groups C22C14/00 or C22C16/00 - C22C 27/04: Alloys based on tungsten or molybdenum - C22C 27/06: Alloys based on chromium - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - C22C: ALLOYS (treatment of alloys C21D, C22F) ## Abstract Embodiments are directed to radiopaque implantable structures (e.g., stents) formed of cobalt-based alloys that comprise cobalt, chromium and one or more platinum group metals, refractory metals, precious metals, or combinations thereof. Platinum group metals include platinum, palladium, ruthenium, rhodium, osmium, and iridium. Refractory metals include zirconium, niobium, rhodium, molybdenum, hafnium, tantalum, tungsten, rhenium, and precious metals include silver and gold. In one embodiment, the one or more included platinum group or refractory metals substitute at least partially for nickel, such that the alloy exhibits reduced nickel content, or is substantially nickel free. The stents exhibit improved radiopacity as compared to similar alloys including greater amounts of nickel. ## Claims ### Claim 1 A radiopaque stent, comprising: a cylindrical main body comprising a cobalt-based alloy comprising cobalt, chromium, an austenitic stabilizer for cobalt including a combination of manganese and nickel, and one or more platinum group metals or precious metals selected from the group of platinum, palladium, rhodium, iridium, osmium, ruthenium, silver and gold; wherein the cobalt-based alloy comprises from 31 weight percent to 51 weight percent cobalt, from 15 weight percent to 20 weight percent chromium, from 8 weight percent to 30 weight percent of the one or more platinum group metals or precious metals; wherein the cobalt-based alloy comprising up to 8 weight percent nickel, up to 20 weight percent manganese, a combined weight percentage of manganese and nickel being up to 25 weight percent, the cobalt-based alloy comprising no more than about 20 percent by weight iron, wherein an entirety of the stent is formed from the cobalt-based alloy. ### Claim 2 (depends on 1) The radiopaque stent of claim 1, wherein the cobalt-based alloy includes from 5.8 weight percent to 7.1 weight percent nickel and includes a combined weight percentage of manganese and nickel that is from 7.7 weight percent to 9.7 weight percent. ### Claim 3 (depends on 1) The radiopaque stent of claim 1, wherein the cobalt-based alloy has a radiopacity from 4.6 barnes/cm3 to 6.5 barnes/cm3. ### Claim 4 (depends on 1) The radiopaque stent of claim 1, wherein the cobalt-based alloy includes 5 weight percent to 8 weight percent nickel. ### Claim 5 (depends on 1) The radiopaque stent of claim 1, wherein the cobalt-based alloy includes from 1 to 5 weight percent manganese. ### Claim 6 (depends on 1) The radiopaque stent of claim 1, wherein the cobalt-based alloy includes a combined weight percentage of manganese and nickel from 7 weight percent to 10 weight percent. ### Claim 7 (depends on 1) The radiopaque stent of claim 1, wherein the cobalt-based alloy includes no more than about 4 percent by weight iron. ### Claim 8 (depends on 1) The radiopaque stent of claim 1, wherein the platinum group metal or precious metal comprises at least one of platinum or palladium. ### Claim 9 (depends on 1) The radiopaque stent of claim 1, wherein the platinum group metal or precious metal comprises both platinum and palladium. ### Claim 10 (depends on 1) The radiopaque stent of claim 1, wherein the alloy further comprises tungsten. ### Claim 11 (depends on 1) The radiopaque stent of claim 1, wherein the alloy further comprises up to 15 weight percent tungsten. ### Claim 12 (depends on 1) The radiopaque stent of claim 1, wherein an entirety of the stent is formed from the cobalt-based alloy. ### Claim 13 (depends on 12) The radiopaque stent of claim 12, wherein the cobalt-based alloy includes from 5.8 weight percent to 7.1 weight percent nickel and includes a combined weight percentage of manganese and nickel that is from 7.7 weight percent to 9.7 weight percent. ### Claim 14 (depends on 12) The radiopaque stent of claim 12, wherein the cobalt-based alloy has a radiopacity from 4.6 barnes/cm3 to 6.5 barnes/cm3. ### Claim 15 (depends on 12) The radiopaque stent of claim 12, wherein the platinum group metal or precious metal comprises at least one of platinum or palladium. ### Claim 16 (depends on 12) The radiopaque stent of claim 12, wherein the platinum group metal or precious metal comprises both platinum and palladium. ### Claim 17 (depends on 12) The radiopaque stent of claim 12, wherein the alloy further comprises tungsten. ### Claim 18 (depends on 12) The radiopaque stent of claim 12, wherein the alloy further comprises up to 15 weight percent tungsten. ### Claim 19 A radiopaque stent, comprising: a cylindrical main body comprising a cobalt-based alloy comprising cobalt, chromium, an austenitic stabilizer for cobalt including a combination of manganese and nickel, and one or more platinum group metals or precious metals selected from the group consisting of platinum, palladium, rhodium, iridium, osmium, ruthenium, silver and gold; wherein the cobalt-based alloy comprises from 31 weight percent to 51 weight percent cobalt, from 15 weight percent to 20 weight percent chromium, from 8 weight percent to 30 weight percent of the one or more platinum group metals or precious metals; wherein the cobalt-based alloy comprises 5 weight percent to 8 weight percent nickel, from 1 weight percent to 5 weight percent manganese, a combined weight percentage of manganese and nickel being from 7 weight percent to 10 weight percent, the cobalt-based alloy comprising no more than about 4 percent by weight iron. ### Claim 20 (depends on 19) The radiopaque stent of claim 19, wherein: (i) the cobalt-based alloy includes from 5.8 weight percent to 7.1 weight percent nickel and includes a combined weight percentage of manganese and nickel that is from 7.7 weight percent to 9.7 weight percent; and/or (ii) wherein the cobalt-based alloy has a radiopacity from 4.6 barnes/cm3 to 6.5 barnes/cm3. ### Claim 21 A radiopaque stent, comprising: a cylindrical main body comprising a cobalt-based alloy comprising cobalt, chromium, an austenitic stabilizer for cobalt including a combination of manganese and nickel, and one or more platinum group metals or precious metals selected from the group of platinum, palladium, rhodium, iridium, osmium, ruthenium, silver and gold; wherein the cobalt-based alloy comprises from 31 weight percent to 51 weight percent cobalt, from 15 weight percent to 20 weight percent chromium, from 8 weight percent to 30 weight percent of the one or more platinum group metals or precious metals; wherein the cobalt-based alloy includes up to 8 weight percent nickel, up to 20 weight percent manganese, a combined weight percentage of manganese and nickel being up to 25 weight percent, the cobalt-based alloy comprising no more than about 20 percent by weight iron, wherein the cobalt-based alloy has a radiopacity from 4.6 barnes/cm3 to 6.5 barnes/cm3.