# US 10,441,406 B2 · Anti-migration micropatterned stent coating > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,441,406 B2 - Document ID: US10441406B2 - Status: Granted - Kind: B2 - Application number: 13/857,998 - Filed: 2013-04-06 - Published: 2013-10-10 - Granted: 2019-10-15 - Earliest claimed: 2012-04-06 - Assignees: Boston Scientific Scimed, Inc. - Applicants: Boston Scientific Scimed, Inc. - Inventors: Laura Elizabeth Firstenberg; Claire M. McLeod; Shannon Taylor; Andrea Lai; Sandra Lam - Web page: https://patentgrep.com/patent/US10441406B2 ## CPC - A61F 2/06: Blood vessels - A61F 2/07: Stent-grafts - A61F 2/90: characterised by a net-like or mesh-like structure - A61F 2/0077: {Special surfaces of prostheses, e.g. for improving ingrowth (A61F2/30767 takes precedence)} - A61F 2002/044: {Oesophagi or esophagi or gullets} - A61F 2230/0078: hyperboloidal - A61F 2250/0026: differing in surface structures - A61F 2250/0039: differing in diameter - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) ## Abstract An endoprosthesis has an expanded state and a contracted state, the endoprosthesis includes a stent having an inner surface defining a lumen and an outer surface; and a polymeric coating adhered to the outer surface of the stent. The polymeric coating includes a base and a plurality of protrusions extending outwardly from the base. When the endoprosthesis is expanded to the expanded state in a lumen defined by a vessel wall, the protrusions apply a force that creates an interlock between the vessel wall and the endoprosthesis. ## Claims ### Claim 1 An endoprosthesis having an expanded state and an unexpanded state, the endoprosthesis comprising: a stent, wherein the stent has an inner surface defining a lumen, an outer surface, a first end, a second end, and a longitudinal axis extending therebetween, and a thickness defined between the inner surface and the outer surface, wherein the stent has a plurality of openings extending through the thickness; an adhesive layer disposed on the outer surface of the stent; and a plurality of spaced apart elongated polymeric strips disposed helically over and adhered to the adhesive layer, each elongated polymeric strip extending at least twice around a circumference of the stent, wherein a portion of the stent is exposed between longitudinally adjacent portions of a single polymeric strip, the plurality of spaced apart polymeric strips comprising a base having an inner surface and an outer surface including a plurality of protrusions extending outwardly from the base, wherein the protrusions are arranged in a micropattern, wherein the base covers the openings of the stent, wherein each of the plurality of protrusions comprises a micropillar, each micropillar extending between a base portion at the base of the polymeric strip and a top surface at an end of the micropillar opposite the base portion. ### Claim 2 (depends on 1) The endoprosthesis of claim 1, wherein when the endoprosthesis assumes the expanded state in a lumen defined by a vessel wall, the micropattern of protrusions is adapted to apply a force that creates an interlock between the vessel wall and the endoprosthesis. ### Claim 3 (depends on 1) The endoprosthesis of claim 1, wherein each of the micropillars includes a columnar portion extending from the base portion toward the top surface, wherein at least a portion of the columnar portion is selected from the group consisting of cylinders, rectangular prisms, and prisms with a polygonal base. ### Claim 4 (depends on 3) The endoprosthesis of claim 3, wherein the micropillars each have a diameter at the base portion and a height extending between the base portion and the top surface. ### Claim 5 (depends on 4) The endoprosthesis of claim 4, wherein the diameter is between 1 μm and 100 μm. ### Claim 6 (depends on 5) The endoprosthesis of claim 5, wherein the diameter is between 14 μm and 18 μm. ### Claim 7 (depends on 4) The endoprosthesis of claim 4, wherein the height is between 1 μm and 100 μm. ### Claim 8 (depends on 7) The endoprosthesis of claim 7, wherein the height is between 14 μm and 18 μm. ### Claim 9 (depends on 4) The endoprosthesis of claim 4, wherein the geometric center of the top surface of the micropillar is separated from the geometric center of the top surface of an adjacent micropillar by a distance greater than the diameter of the micropillar. ### Claim 10 (depends on 1) The endoprosthesis of claim 1, wherein each protrusion of the micropattern has a height between the base portion and the top surface, and a diameter at the base portion, wherein the height is between 1 μm and 100 μm, wherein the diameter is between 1 μm and 100 μm, and wherein a ratio between height and the diameter is between 1 and 1.3. ### Claim 11 (depends on 1) The endoprosthesis of claim 1, wherein the polymeric member is made from a polymeric material selected from the group consisting of hydrogels and silicones. ### Claim 12 (depends on 1) The endoprosthesis of claim 1, wherein the protrusions of the micropattern are hollow. ### Claim 13 (depends on 1) The endoprosthesis of claim 1, wherein the micropattern includes protrusions of a first configuration and protrusions of at least a second configuration. ### Claim 14 (depends on 1) The endoprosthesis of claim 1, wherein first and second opposing walls of the micropillar extend between the base portion and the top surface at first and second angles, respectively, wherein the first and second angles are different from each other, and a geometric center of the base portion is offset laterally from a geometric center of the top surface. ### Claim 15 (depends on 1) The endoprosthesis of claim 1, wherein the micropillars have an outer surface, wherein at least some of the micropillars have recesses in their outer surface, the recesses distributed over substantially the entire outer surface. ### Claim 16 An endoprosthesis having an expanded state and an unexpanded state, the endoprosthesis comprising: a stent, wherein the stent has an inner surface defining a lumen, an outer surface, a first end, a second end, and a thickness defined between the inner surface and the outer surface, wherein the stent has a plurality of openings extending through the thickness; and a polymeric member adhered to the outer surface of the stent, the polymeric member comprising a base having an inner surface adhered to the stent and an outer surface including a plurality of elongate protrusions extending outwardly from the base, wherein the plurality of elongate protrusions are arranged in one or more different micropatterns, wherein each of the plurality of elongate protrusions extends from the base to a concave top surface. ### Claim 17 (depends on 16) The endoprosthesis of claim 16, wherein each elongate protrusion of the plurality of elongate protrusions has a height and a diameter at a base of the protrusion, wherein height is between 1 μm and 100 μm, wherein the diameter is between 1 μm and 100 μm, and wherein a ratio between the height and the diameter is between 1 and 1.3. ### Claim 18 (depends on 17) The endoprosthesis of claim 17, wherein a geometric center of each elongate protrusion of the plurality of elongate protrusions is spaced apart from a geometric center of adjacent elongate protrusions by a spacing between elongate protrusions, wherein a ratio of the spacing to the diameter is between 2.1 and 2.4. ### Claim 19 An endoprosthesis having an expanded state and an unexpanded state, the endoprosthesis comprising: a stent, wherein the stent has an inner surface defining a lumen, an outer surface, a first end, a second end, and a longitudinal axis extending therebetween, and a thickness defined between the inner surface and the outer surface, wherein the stent has a plurality of openings extending through the thickness; and a plurality of spaced apart elongated polymeric strips adhered to the stent with an adhesive layer, each of the plurality of elongated spaced apart polymeric strips extending helically around a circumference of the stent at least twice, each strip comprising a base having an inner surface facing the stent and an outer surface including a plurality of protrusions extending outwardly from the base, wherein the plurality of protrusions are arranged in one or more different micropatterns, wherein each of the plurality of protrusions extends between a base portion at the base of the polymeric strip and a top surface at an end of the protrusion opposite the base portion, wherein the top surface of each protrusion is concave, wherein the outer surface of the stent is exposed between longitudinally adjacent portions of a single polymeric strip and between the plurality of spaced apart polymeric strips. ### Claim 20 (depends on 19) The endoprosthesis of claim 19, wherein for at least some of the plurality of protrusions, first and second opposing walls of each protrusion extend between the base and a top surface of the protrusion at first and second angles, respectively, wherein the first and second angles are different from each other. ### Claim 21 (depends on 19) The endoprosthesis of claim 19, wherein a geometric center at the base of at least some of the plurality of protrusions is offset laterally from a geometric center of a top surface of the protrusion.