# US 10,441,336 B2 · Stabilization of vertebral bodies with bone particle slurry

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- Number: US 10,441,336 B2
- Document ID: US10441336B2
- Status: Granted
- Kind: B2
- Application number: 16/016,635
- Filed: 2018-06-24
- Published: 2018-12-20
- Granted: 2019-10-15
- Earliest claimed: 2017-06-14
- Assignees: Osteoagra LLC
- Applicants: Osteoagra LLC
- Inventors: Neville Alleyne
- Web page: https://patentgrep.com/patent/US10441336B2

## CPC

- A61B 17/8822: {characterised by means facilitating expulsion of fluid from the introducer, e.g. a screw pump plunger, hydraulic force transmissions, application of vibrations or a vacuum}
- A61B 17/8805: {for introducing fluid filler into bone or extracting it (A61B17/7097, A61B17/8833 take precedence)}
- A61B 17/8816: {characterised by the conduit, e.g. tube, along which fluid flows into the body or by conduit connections}
- A61B 17/8827: {with filtering, degassing, venting or pressure relief means}
- A61B 17/8833: {Osteosynthesis tools specially adapted for handling bone cement or fluid fillers; Means for supplying bone cement or fluid fillers to introducing tools, e.g. cartridge handling means}
- A61F 2/2846: {Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects (nets or sleeves applied to surface of endoprostheses A61F2/30907; bone plates A61B17/80; bone regeneration in dental surgery A61C8/0006)}
- A61F 2/30723: {Plugs or restrictors for sealing a cement-receiving space (tools for inserting plugs A61F2/4614; sealing collars for use during cementing A61B17/8808)}
- A61L 27/025: {Other specific inorganic materials not covered by A61L27/04 - A61L27/12}
- A61L 27/06: Titanium or titanium alloys
- A61L 27/16: obtained by reactions only involving carbon-to-carbon unsaturated bonds
- A61L 27/3608: {Bone, e.g. demineralised bone matrix [DBM], bone powder}
- A61L 27/365: {Bones}
- A61L 27/50: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61L 27/58: Materials at least partially resorbable by the body
- A61B 2017/8838: {for mixing bone cement or fluid fillers}
- A61B 2217/005: with suction drainage system
- A61F 2/44: for the spine, e.g. vertebrae or spinal discs
- A61F 2002/2835: {Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material}
- A61F 2002/30677: {Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body}
- A61F 2310/00359: Bone or bony tissue
- A61L 2400/06: Flowable or injectable implant compositions
- A61L 2430/38: for reconstruction of the spine, vertebrae or intervertebral discs
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

A medical implant comprises a slurry of bone particles that are injected into a vertebral body under pressure. The liquid component of the slurry may be aspirated while the slurry is being injected so that the bone particles of the slurry pack into the central area of the vertebral body to provide structural support. The injected slurry may be agitated during the procedure to maximize the structural strength of the implant after the procedure.

## Claims

### Claim 1

A method of structurally supporting a vertebral body comprising:
forming one or more openings to a central portion of a vertebral body and placing a cannula through a first opening of the one or more openings;
injecting a slurry of bone particles through the cannula, wherein the slurry of bone particles consists essentially of bone particles, water, and optionally one or more additional ingredients selected from salts, growth factor, blood, platelets, contrast agent, stem cells, antibiotics, chemotherapeutic agents, bisphosphonates, and osteoporosis therapy drugs,
pressurizing the slurry during and/or after the injecting to force bone particles of the slurry into direct contact with bone tissue inside the vertebral body.

### Claim 2 (depends on 1)

The method of claim 1 comprising:
inserting a catheter into the central portion of the vertebral body through the cannula;
injecting the slurry of bone particles through the catheter.

### Claim 3 (depends on 1)

The method of claim 1 comprising:
removing the cannula; and
inserting a plug into the first opening.

### Claim 4 (depends on 1)

The method of claim 1, comprising aspirating liquid from the central portion of the vertebral body.

### Claim 5 (depends on 1)

The method of claim 1, comprising agitating the slurry in the vertebral body during the injecting.

### Claim 6 (depends on 1)

The method of claim 1, comprising forming at least a second opening to the central portion of the vertebral body.

### Claim 7 (depends on 6)

The method of claim 6, comprising
placing a second cannula through the second opening of the one or more openings;
injecting a slurry of bone particles through the second cannula at the same time as injecting a slurry of bone particles through the first cannula.

### Claim 8 (depends on 6)

The method of claim 6, comprising:
placing a second cannula through the second opening of the one or more openings;
aspirating liquid from the central portion of the vertebral body through the second cannula while injecting the slurry of bone particles through the first cannula.

### Claim 9

A method of structurally supporting a vertebral body comprising:
forming one or more openings to a central portion of a vertebral body and placing a cannula through a first opening of the one or more openings;
injecting a slurry of bone particles through the cannula, wherein the slurry of bone particles is 20 to 85 percent bone by volume, and
pressurizing the slurry during and/or after the injecting to force bone particles of the slurry into direct contact with bone tissue inside the vertebral body.

### Claim 10 (depends on 9)

The method of claim 9, wherein at least 90% of the bone particles are non-demineralized cortical bone particles.