# US 10,441,301 B2 · Devices and methods for removal of acute blockages from blood vessels > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,441,301 B2 - Document ID: US10441301B2 - Status: Granted - Kind: B2 - Application number: 14/737,249 - Filed: 2015-06-11 - Published: 2015-12-17 - Granted: 2019-10-15 - Earliest claimed: 2014-06-13 - Assignees: Neuravi Limited - Applicants: Neuravi Limited - Inventors: David Vale; Brendan Casey; Michael Gilvarry; Kevin Mcardle; Maeve Holian; David Hardiman; Alan Keane; Daniel King - Web page: https://patentgrep.com/patent/US10441301B2 ## CPC - A61B 17/22032: {having inflatable gripping elements (balloon catheters A61M25/10)} - A61B 17/22: Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for - A61B 17/221: Gripping devices in the form of loops or baskets {for gripping calculi or similar types of obstructions (surgical snare instruments A61B17/32056)} - A61M 1/74: {Suction control (underwater drainage A61M1/61)} - A61M 1/84: {Drainage tubes; Aspiration tips (for negative pressure wound therapy A61M1/90; for surgical cutting instruments A61B17/32)} - A61M 25/0082: {Catheter tip comprising a tool} - A61B 2017/00778: {Operations on blood vessels (A61B2017/22097, A61B2017/320741 take precedence)} - A61B 2017/22051: {with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation (A61B2017/22048, A61B2017/3486 take precedence)} - A61B 2017/22067: {Blocking; Occlusion (A61B2017/22054 takes precedence)} - A61B 2017/22079: {with suction of debris} - A61B 2017/2215: {having an open distal end} - A61B 2017/3435: {using everted sleeves} - A61M 2210/12: Blood circulatory system - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A rapid exchange (RX) catheter may provide a proximal seal against a guide catheter inner lumen so that aspiration may be applied through a guide catheter. The catheter may include an exit port that defines a transfer port for aspiration and may enable minimal frictional engagement with the guide catheter proximal of the exit port. Aspiration can be applied to the lumen of the guide catheter and may be directed to and effective at the tip of the RX aspiration catheter. A tip of the RX catheter may facilitate aspiration and retrieval of the clot by expanding under load and can also partially or fully occlude the vessel. ## Claims ### Claim 1 A system for treating an occlusion in a vessel the system comprising: a guide catheter comprising a proximal end, a distal end and a lumen extending between the proximal end and the distal end, the lumen of the guide catheter further comprising a proximal segment and a distal segment; an aspiration catheter disposed in and advanceable through the guide catheter, the aspiration catheter comprising a distal end and a proximal end, a distal segment and a proximal segment, and a lumen, said lumen of the aspiration catheter extending proximal of the distal end and terminating at a transfer port at the proximal end of the aspiration catheter; a microcatheter advanceable through the guide catheter and the aspiration catheter, the microcatheter capable of being retracted proximal of the transfer port; the guide catheter being configured to facilitate aspiration through the microcatheter and the lumen, and the transfer port of the aspiration catheter; the transfer port being configured to transmit aspiration in the proximal segment of the lumen of the aspiration catheter into the lumen of the distal segment of the guide catheter and the distal end of the aspiration catheter being configured to receive the occlusion into at least a portion of the lumen of the aspiration catheter a flow restrictor between the guide catheter and the distal segment of the aspiration catheter, distal of the transfer port, wherein the flow restrictor is located on an inner surface of the guide catheter, and wherein the transfer port is connected to the guide catheter through a minimal frictional engagement. ### Claim 2 (depends on 1) The system as claimed in claim 1, further comprising a proximal flow restrictor distal of the proximal end of the distal segment of the aspiration catheter and a distal flow restrictor spaced distally from the proximal flow restrictor. ### Claim 3 (depends on 1) The system as claimed in claim 1, wherein the flow restrictor is actuatable between engaged and disengaged configuration. ### Claim 4 (depends on 3) The system as claimed in claim 3, further comprising an actuator for selectively engaging and/or disengaging the flow restrictor. ### Claim 5 (depends on 4) The system as claimed in claim 4, the flow restrictor comprises a framework and a membrane coupled to the framework, the framework being movable by the actuator between an expanded configuration and a retracted configuration. ### Claim 6 (depends on 1) They system as claimed in claim 1, wherein the distal end of the aspiration catheter comprises a mouth for reception of clot. ### Claim 7 (depends on 6) The system as claimed in claim 6, wherein the mouth is defined by an expansile tip. ### Claim 8 (depends on 6) The system as claimed in claim 6, wherein the distal segment includes a hinge adjacent to the distal mouth. ### Claim 9 (depends on 8) The system as claimed in claim 8, wherein the hinge is defined by a region of the distal segment which is configured to have lateral flexibility. ### Claim 10 (depends on 6) The system as claimed in claim 6, wherein the mouth has an expanded configuration and a retracted configuration. ### Claim 11 (depends on 10) The system as claimed in claim 10, further comprising a control member for controlling the movement of the mouth between the expanded and retracted configurations. ### Claim 12 (depends on 11) The system as claimed in claim 11, wherein the mouth comprises a number of segments and the control member is configured to move at least some of the segments. ### Claim 13 (depends on 12) The system as claimed in claim 12, wherein the control member comprises a drawstring. ### Claim 14 (depends on 1) The system as claimed in claim 1, further comprising a clot engaging device for delivery from the microcatheter. ### Claim 15 (depends on 14) The system as claimed in claim 14, wherein the guide catheter is mounted in a proximal rotating hemostasis valve through which aspiration is applied. ### Claim 16 (depends on 14) The system as claimed in claim 14, wherein a proximal end of the microcatheter and a proximal end of the aspiration catheter are locatable within separate branches of a proximal rotating hemostasis valve. ### Claim 17 (depends on 1) The system as claimed in claim 1, wherein the microcatheter and the aspiration catheter are capable of being introduced together in the guide catheter.