# US 10,441,202 B2 · Methods and systems for assisting persons, product providers and/or service providers

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- Number: US 10,441,202 B2
- Document ID: US10441202B2
- Status: Granted
- Kind: B2
- Application number: 14/892,186
- Filed: 2014-05-23
- Published: 2016-12-29
- Granted: 2019-10-15
- Earliest claimed: 2013-05-23
- Assignees: iPhenotype LLC
- Applicants: iPhenotype LLC
- Inventors: Jay M. Short; Steve Briggs
- Web page: https://patentgrep.com/patent/US10441202B2

## CPC

- G16H 20/00: ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- A61B 3/113: for determining or recording eye movement
- A61B 5/02055: {Simultaneously evaluating both cardiovascular condition and temperature}
- A61B 5/14546: {for measuring analytes not otherwise provided for, e.g. ions, cytochromes}
- A61B 5/1459: invasive, e.g. introduced into the body by a catheter
- A61B 5/1473: invasive, e.g. introduced into the body by a catheter
- A61B 5/165: {Evaluating the state of mind, e.g. depression, anxiety}
- A61B 5/4875: {Hydration status, fluid retention of the body}
- A61B 5/7246: {using correlation, e.g. template matching or determination of similarity}
- G06F 16/285: {Clustering or classification}
- G06F 16/9535: Search customisation based on user profiles and personalisation
- G06F 16/9536: Search customisation based on social or collaborative filtering
- G06Q 30/02: Marketing; Price estimation or determination; Fundraising
- G06Q 30/0631: {Recommending goods or services}
- G09B 5/12: different stations being capable of presenting different information simultaneously (G09B5/14 takes precedence)
- G09B 19/00: Teaching not covered by other main groups of this subclass (teaching or practice apparatus for gun-aiming or gun-laying F41G3/26)
- G16B 20/00: ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B 20/20: Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
- G16B 40/30: Unsupervised data analysis
- G16H 10/20: for electronic clinical trials or questionnaires
- G16H 40/63: for local operation
- G16H 50/70: for mining of medical data, e.g. analysing previous cases of other patients
- A61B 5/021: Measuring pressure in heart or blood vessels
- A61B 5/024: Measuring pulse rate or heart rate
- A61B 5/05: Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves (measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24)
- A61B 5/0816: {Measuring devices for examining respiratory frequency (measuring frequency of electric signals G01R23/00)}
- G16B 40/00: ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G06F: ELECTRIC DIGITAL DATA PROCESSING (computer systems based on specific computational models G06N)
- G06Q: INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G09B: EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS (devices for psychotechnics or for testing reaction times A61B5/16; games, sports, amusements A63; projectors, projector screens G03B)
- G16B: BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY

## Abstract

A method of assisting daily living for an individual, comprising the steps of measuring a presence and/or concentration of one or more biomarkers in a sample from the individual; predicting a behavior or emotional state of the individual based on the measured presence and/or concentration of the one or more biomarkers by applying a correlation between human biological phenotype and human behavioral and/or emotional phenotype; and altering the living environment of the individual or providing information, advice or guidance to the individual based on the predicted behavior or emotional state of the individual, where the correlation between human biological phenotype and human behavioral and/or emotional phenotype comprises a correlation between the one or more biomarkers and a behavior or emotional state. A system for assisting daily living for an individual is also provided. The present invention is useful for product and service providers and industries for purposes of standardizing or rating product quality and efficacy, and/or for promotion and selling purposes.

## Claims

### Claim 1

A method of assisting daily living of an individual, comprising the steps of:
measuring a presence and/or concentration of at least two biomarkers comprising a polypeptide and a metabolite in a urine sample from the individual with a measuring device located in a urinal or toilet;
predicting a behavior or emotional state of the individual based on the measured presence and/or concentration of the at least two biomarkers comprising a polypeptide and a metabolite by applying a correlation between human biological phenotype and human behavioral and/or emotional phenotype; and
altering the living environment of the individual based on the predicted behavior or emotional state of the individual,
wherein the correlation between human biological phenotype and human behavioral and/or emotional phenotype comprises a correlation between the at least two biomarkers comprising a polypeptide and a metabolite and a behavior or emotional state.

### Claim 2 (depends on 1)

The method of claim 1, wherein the at least two biomarkers further comprises at least one of polynucleotides, microbes, inorganic compounds, and ions.

### Claim 3 (depends on 2)

The method of claim 2, wherein the presence or concentration of the at least two biomarkers is measured by using recognition molecules selected from antibodies, antigens, aptamers, natural receptors, synthetic receptors, ligands, enzymes, enzymatic substrates, nuclei acid probes.

### Claim 4 (depends on 2)

The method of claim 2, wherein the measuring step is carried out using one or more biosensors comprising a transducer selected from optical transducers, mass-based transducers, magnetic field based transducers, electrochemical transducers, and calorimetric transducers.

### Claim 5 (depends on 2)

The method of claim 2, wherein the presence or concentration of at least two biomarkers in the sample is measured by one or more electrodes selected from potentiometric electrodes, amperometric electrodes and conductometric electrodes.

### Claim 6 (depends on 2)

The method of claim 2, wherein the presence or concentration of the at least two biomarkers is measured by an array of recognition molecules selected from antibodies, aptamers, oligonucleotides and combinations thereof.

### Claim 7 (depends on 1)

The method of claim 1, wherein the measuring step further comprises measuring a physiological parameter of the individual selected from body temperature, pulse rate, blood pressure, respiratory rate, hydration status, electromuscular activity, eye movement and combinations thereof.

### Claim 8 (depends on 1)

The method of claim 1, wherein the presence and/or concentration measured in said measuring step is correlated with location data associated with a location wherein said measurement is made.

### Claim 9 (depends on 8)

The method of claim 8, wherein the location data is data associated with the location selected from temperature, altitude noise, altitude, wind, humidity, pollution, oxygen, sunshine, pollen, crowd density, concrete, grass, night, day, near highway and traffic density at that time, aircraft flying, cosmic radiation levels, radon exposure, clothing and combinations thereof.

### Claim 10 (depends on 1)

The method of claim 1, wherein altering the living environment of the individual comprises an alteration selected from adjusting brightness and/or color of lighting, adjusting room temperature, adjusting humidity, rearranging furniture, playing music, adjusting a volume of music or audio, changing a TV channel, playing a recorded voice or sound, changing an appearance of a wall or screen, retracting a roof, opening or closing a window, adjusting oxygen concentration in air, adding or adjusting a scent in air, introducing one or more air-borne chemicals into air, and altering one or more of a display and web search results.

### Claim 11 (depends on 1)

The method of claim 1, further comprising the step of providing information, advice or guidance to the individual, wherein the information, advice or guidance comprises a course of action selected from a course of action for performing the predicted behavior, a course of action for preventing or mitigating the predicted behavior, a course of action for better coping with the predicted emotional state and combinations thereof.

### Claim 12 (depends on 1)

The method of claim 1, further comprising the step of providing information, advice or guidance to the individual, wherein the information, advice or guidance comprises
suggesting one or more products selected from supplements, vitamins, beverages, beauty products, personal care products, weight loss products, skin care products, sports supplements, extracts, probiotics, seasonings, flavors, sweeteners, taste/aroma blockers/modifiers, bulking agents, video games, electronics, reading materials, music, movies, TV programs, live shows, apparel, accessories, footwear, home appliances, exercise equipment, types of food, boats, automobiles, bikes, restaurants, office supplies, furniture, and vacation resorts/destinations;
suggesting one or more services selected from messaging, financial services, dating services, catering services, home cleaning services, home improvement services, hair dressing services, cosmetic services, professional counseling services, travel services, casino gaming services, shopping services, real estate services, sports-related services, entertainment services, online auction services and hospitality services; or
suggesting at least one promotion or coupon for a product or service.

### Claim 13 (depends on 12)

The method of claim 12, further comprising the step of suggesting a local business and/or providing a map location of a local business in relation to the information, advice or guidance, wherein the information, advice or guidance involves suggesting a product or a service, and the local business provides the suggested product or service.

### Claim 14

A system for assisting an individual in daily living, comprising:
a measuring device located in a toilet or urinal for measuring a presence and/or concentration of at least two biomarkers comprising a polypeptide and a metabolite in a urine sample from the individual;
a predictor for predicting a behavior or emotional state of the individual based on the measured presence and/or concentration of the at least two biomarkers comprising a polypeptide and a metabolite by applying a correlation between human biological phenotype and human behavioral and/or emotional phenotype;
an assistance device for altering the living environment of the individual based on the predicted behavior or emotional state of the individual; and
a database for storing correlations between human biological phenotype and human behavioral and/or emotional phenotype, wherein the correlation between human biological phenotype and human behavioral and/or emotional phenotype comprises a correlation between the at least two biomarkers comprising a polypeptide and a metabolite and a behavior or emotional state.

### Claim 15 (depends on 14)

The system of claim 14, wherein the predictor and the assistance device are part of an electronic device selected from smartphones, tablet computers, notebook computers, e-book readers, mobile internet devices, personal digital assistants, internet phones, holographic devices, holographic phones, cable internet devices, satellite internet devices, internet televisions, digital subscriber line (DSL) internet devices and remote controls.

### Claim 16 (depends on 14)

The system of claim 14, further comprising a supplementary measuring device for measuring at least one physiological parameter selected from body temperature, pulse rate, blood pressure, respiratory rate, hydration status, eye movement, electromuscular activity and combinations thereof.

### Claim 17 (depends on 14)

The system of claim 14, further comprising an apparatus for correlating measured presence and/or concentration of the at least two biomarkers with time at a location wherein said measurement is made.

### Claim 18 (depends on 17)

The system of claim 17, wherein the predictor considers additional data from the location selected from temperature, altitude noise, altitude, wind, humidity, pollution, oxygen, sunshine, pollen, crowd density, concrete, grass, night, day, near highway and traffic density at that time, aircraft flying, cosmic radiation levels, radon exposure, clothing and combinations thereof that are correlated with one or more measurements taken in said measuring step.

### Claim 19 (depends on 14)

The system of claim 14, wherein the measuring device comprises one or more biosensors including a structure selected from a giant magnetoresistance structure, a nanowire, a microfluidic circuit, a nanotube and a biochip.

### Claim 20 (depends on 14)

The system of claim 14, wherein the measuring device comprises one or more electrodes selected from potentiometric electrodes, amperometric electrodes and conductometric electrodes.

### Claim 21 (depends on 14)

The system of claim 14, wherein the measuring device comprises an array selected from antibody arrays, aptamer arrays, oligonucleotide arrays and combinations thereof.

### Claim 22 (depends on 14)

The system of claim 14, wherein the assistance device further provides information, advice or guidance to the individual,
the system further comprises an apparatus for suggesting a local business and/or providing a map location of a local business in relation to the information, advice or guidance, wherein the information, advice or guidance involves suggesting a product or a service, and the local business provides the suggested product or service.

### Claim 23 (depends on 14)

The system of claim 14, wherein the system is implemented using an electronic device selected from smartphones, tablet computers, notebook computers, e-book readers, mobile internet devices, personal digital assistants, internet phones, holographic devices, holographic phones, cable internet devices, satellite internet devices, internet televisions, digital subscriber line (DSL) internet devices and remote controls.

### Claim 24 (depends on 23)

The system of claim 23, wherein the assistance device further provides information, advice or guidance to the individual, and the electronic device is configured for providing a map location of business in relation to the information, advice or guidance, wherein the information, advice or guidance is suggesting a product or a service, and the business provides the product or service.

### Claim 25 (depends on 23)

The system of claim 23, wherein the assistance device further provides information, advice or guidance to the individual, and the electronic device is configured for obtaining feedback on a suggested product or a service, and the feedback is suitable for being used to rank the product or service, and wherein the information, advice or guidance is suggesting the product or service.