# US 10,441,201 B2 · Noninvasive mid-infrared in vivo glucose sensor

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,441,201 B2
- Document ID: US10441201B2
- Status: Granted
- Kind: B2
- Application number: 14/470,386
- Filed: 2014-08-27
- Published: 2015-03-05
- Granted: 2019-10-15
- Earliest claimed: 2013-08-27
- Assignees: The Trustees of Princeton Univerisity
- Applicants: Sabbir Liakat; Claire F. Gmachl; Anna P. M. Michel; Kevin Bors
- Inventors: Sabbir Liakat; Claire F. Gmachl; Anna P. M. Michel; Kevin Bors
- Web page: https://patentgrep.com/patent/US10441201B2

## CPC

- A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement}
- A61B 5/1455: using optical sensors, e.g. spectral photometrical oximeters
- A61B 5/1495: Calibrating or testing of in-vivo probes
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A noninvasive mid-infrared in vivo glucose sensor for use in connection with the skin of a test subject is disclosed. The sensor includes a mid-infrared light source configured to deliver a light beam to the skin of the test subject, a collector element configured to collect backscattered light from the skin and direct it to the detector, and a detector element configured to measure the collected backscattered light from the skin. The mid-infrared light source may be a quantum cascade laser. The sensor may include optical fibers configured to deliver the light beam to the skin of the test subject. The collector element may be an integrating sphere or a bundle of two or more optical fibers. The sensor may also include a probe containing or connecting to optical fibers coupled to the mid-infrared light source and configured to be placed on the skin to take glucose level readings.

## Claims

### Claim 1

A noninvasive mid-infrared in vivo glucose sensor for use in connection with interstitial fluid in the skin of a test subject, the sensor comprising:
a mid-infrared light source configured to deliver a light beam to the skin of the test subject, the mid-infrared light source capable of being tuned to between around 1000 cm−1 to around 1200 cm−1; and
a collector element configured to collect light having a plurality of wavelengths from the skin and direct all of the collected light to an optical detector element without passing through a filter, the optical detector element configured to measure the collected light from the skin at the plurality of wavelengths.

### Claim 2 (depends on 1)

A sensor according to claim 1, wherein the mid-infrared light source is a quantum cascade laser.

### Claim 3 (depends on 1)

A sensor according to claim 1, further comprising optical fibers configured to deliver the light beam to the skin of the test subject.

### Claim 4 (depends on 3)

A sensor according to claim 3, wherein the optical fibers are hollow core optical fibers.

### Claim 5 (depends on 1)

A sensor according to claim 1, wherein the collector element is an integrating sphere.

### Claim 6 (depends on 1)

A sensor according to claim 1, wherein the collector element is a bundle of two or more optical fibers.

### Claim 7 (depends on 1)

A sensor according to claim 1, further comprising:
a probe containing or connecting to optical fibers coupled to the mid-infrared light source;
wherein the probe is configured to be placed on the skin of the test subject to take glucose level readings.

### Claim 8 (depends on 1)

A sensor according to claim 1, wherein the mid-infrared light source is tuned to between around 1040 cm−1 to around 1180 cm−1.

### Claim 9 (depends on 1)

A sensor according to claim 1, wherein the mid-infrared light source is tuned to between around 1070 cm−1 to around 1090 cm−1.

### Claim 10 (depends on 1)

A sensor according to claim 1, further comprising a spacer configured to locate the collector element at an optimal distance.

### Claim 11

A noninvasive mid-infrared in vivo glucose sensor for use in connection with interstitial fluid in the skin of a test subject, the sensor comprising:
a mid-infrared light source configured to deliver a light beam to the skin of the test subject, the mid-infrared light source capable of being tuned to between around 1000 cm−1 to around 1200 cm−1; and
a collector element configured to collect light having a plurality of wavelengths from the skin and direct all of the collected light to an optical detector element configured to measure the collected light from the skin at the plurality of wavelengths,
wherein the mid-infrared light source is configured to provide a peak power greater than 100 milliwatts and an average power of less than 10 milliwatts.