# US 10,440,972 B2 · Liquid milk fortifier composition with relatively high lipid content

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- Number: US 10,440,972 B2
- Document ID: US10440972B2
- Status: Granted
- Kind: B2
- Application number: 15/038,619
- Filed: 2013-11-29
- Published: 2016-10-13
- Granted: 2019-10-15
- Earliest claimed: 2013-11-29
- Assignees: Societe des Produits Nestle S.A.
- Applicants: Nestec S.A.
- Inventors: Laurent Ameye; Marilisa Hamaoka-Hermann; Simona Stan; Sze Tan
- Web page: https://patentgrep.com/patent/US10440972B2

## CPC

- A23C 9/1522: {Inorganic additives, e.g. minerals, trace elements; Chlorination or fluoridation of milk; Organic salts or complexes of metals other than natrium or kalium; Calcium enrichment of milk}
- A23C 9/1526: {Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof}
- A23C 9/1528: {Fatty acids; Mono- or diglycerides; Petroleum jelly; Paraffine; Phospholipids; Derivatives thereof}
- A23C 9/158: containing vitamins or antibiotics
- A23L 33/115: Fatty acids or derivatives thereof; Fats or oils
- A23L 33/12: Fatty acids or derivatives thereof
- A23L 33/15: Vitamins
- A23L 33/16: Inorganic salts, minerals or trace elements
- A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula}
- A61K 31/047: having two or more hydroxy groups, e.g. sorbitol
- A61K 31/07: Retinol compounds, e.g. vitamin A (retinoic acids A61K31/203)
- A61K 31/122: having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K 31/14: Quaternary ammonium compounds, e.g. edrophonium, choline (betaines A61K31/205)
- A61K 31/185: Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids (hydroxamic acids A61K31/16; peroxy acids A61K31/327)
- A61K 31/197: the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid (carnitine A61K31/205)
- A61K 31/201: having one or two double bonds, e.g. oleic, linoleic acids
- A61K 31/202: having three or more double bonds, e.g. linolenic (eicosanoids, e.g. leukotrienes A61K31/557)
- A61K 31/205: Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
- A61K 31/355: Tocopherols, e.g. vitamin E
- A61K 31/375: Ascorbic acid, i.e. vitamin C; Salts thereof
- A61K 31/4188: condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
- A61K 31/4415: Pyridoxine, i.e. Vitamin B6 (pyridoxal phosphate A61K31/675)
- A61K 31/455: Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
- A61K 31/51: Thiamines, e.g. vitamin B1
- A61K 31/519: ortho- or peri-condensed with heterocyclic rings
- A61K 31/525: Isoalloxazines, e.g. riboflavins, vitamin B2
- A61K 31/59: Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K 31/685: one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
- A61K 31/70: Carbohydrates; Sugars; Derivatives thereof (sorbitol A61K31/047)
- A61K 31/714: Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
- A61K 33/00: Medicinal preparations containing inorganic active ingredients
- A61K 33/16: Fluorine compounds
- A61K 33/18: Iodine; Compounds thereof
- A61K 33/24: Heavy metals; Compounds thereof
- A61K 33/26: Iron; Compounds thereof
- A61K 33/30: Zinc; Compounds thereof
- A61K 33/32: Manganese; Compounds thereof
- A61K 33/34: Copper; Compounds thereof
- A61K 33/42: Phosphorus; Compounds thereof
- A61K 35/741: Probiotics (probiotic yeast, e.g. saccharomyces A61K36/06)
- A61K 38/1709: {from mammals}
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K 2035/115: {Probiotics}
- A23C: DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF (preservation thereof A23B11/00)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

The present invention relates to a liquid milk fortifier composition for administration to infants, which fortifier composition comprises lipids in an amount of above 75% of the caloric content. The fortifier may be administrated to infants either as a supplement to human breast milk or to infant formulas. The present invention also relates to the use of the fortifier composition as well as a kit of parts for use in providing a lipid and/or calorie adapted body weight dependent nutrition to infants.

## Claims

### Claim 1

A method for fortifying a product selected from the group consisting of human breast milk, an infant formula and a growing-up milk, the method comprising adding a liquid milk fortifier composition to the product, the liquid milk fortifier composition comprising lipid in an amount of above 75% of the caloric content of the liquid milk fortifier composition, the lipid comprises medium-chain triglycerides in an amount of 20% to 40% by weight of a total content of the lipid and further comprises alpha-linolenic acid in an amount of 0.9% to 30% by weight of the total content of the lipid.

### Claim 2

A method for increasing the growth and/or the energy intake of an infant or a child, the method comprising administering to the infant or child a composition comprising a liquid milk fortifier composition comprising lipid in an amount of above 75% of the caloric content of the liquid milk fortifier composition, the lipid comprises medium-chain triglycerides in an amount of 20% to 40% by weight of a total content of the lipid and further comprises alpha-linolenic acid in an amount of 0.9% to 30% by weight of the total content of the lipid.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the lipid further comprises a component selected from the group consisting of monoglycerides, diglycerides, phospholipids, cholesterol, free fatty acids, derivatives of fatty acids, and combination s thereof.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the lipid comprises phospholipid.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the lipid further comprises a component selected from the group consisting of arachidonic acid, docosahexaenoic acid, eicosapentaenoic acid, linoleic acid, phospholipid, milk fat, structured lipids, and combinations thereof.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the liquid milk fortifier composition further comprises one or more vitamins.

### Claim 7 (depends on 6)

The method according to claim 6, wherein the one or more vitamins are lipid-soluble.

### Claim 8 (depends on 1)

The method according to claim 1, wherein the liquid milk fortifier composition further comprises one or more minerals.

### Claim 9 (depends on 1)

The method according to claim 1, wherein the liquid milk fortifier composition further comprises protein.

### Claim 10 (depends on 1)

The method according to claim 1, wherein the liquid milk fortifier composition further comprises carbohydrates.

### Claim 11 (depends on 1)

The method according to claim 1, wherein the liquid milk fortifier composition further comprises probiotics.

### Claim 12 (depends on 1)

The method according to claim 1, wherein the liquid milk fortifier composition further comprises prebiotics.

### Claim 13 (depends on 1)

The method according to claim 1, wherein the lipid is provided by one or more oils or fats.

### Claim 14 (depends on 13)

The method according to claim 13, wherein the one or more oils or fats are selected from the group consisting of coconut oil, soy oil, corn Oil, olive oil, safflower oil, medium chain triglyceride oil, sunflower oil, palm oil, palm kernel oil, canola oil, marine oil, cottonseed oil, milk fat, egg-derived oils, fungal oils, algal oils, structured lipids, and combinations thereof.

### Claim 15 (depends on 1)

The method according to claim 1, wherein the lipid further comprises arachidonic acid that is 0.2 to 2 wt. % of the total content of the lipid and docosahexaenoic acid that is 0.1 to 1.5 wt. % of the total content of the lipid.

### Claim 16 (depends on 1)

The method according to claim 1, wherein the lipid further comprises phospholipid in an amount of 0.5% to 20% by weight of the total content of the lipid.