# US 10,440,952 B2 · Use of active substances for controlling virus infection in plants > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,440,952 B2 - Document ID: US10440952B2 - Status: Granted - Kind: B2 - Application number: 16/069,242 - Filed: 2017-01-12 - Published: 2019-01-24 - Granted: 2019-10-15 - Earliest claimed: 2016-01-13 - Assignees: Bayer Corp Science AG - Applicants: Bayer CropScience Aktiengesellschaft - Inventors: Rachel Baltz; David Bernier; Florence Jay-Brioudes; Thomas Knobloch; Maxime Vitel; Olivier Voinnet - Web page: https://patentgrep.com/patent/US10440952B2 ## CPC - A01N 43/80: five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2 - A01G 7/06: Treatment of growing trees or plants, e.g. for preventing decay of wood, for tingeing flowers or wood, for prolonging the life of plants - A61P 31/12: Antivirals - C07D 261/12: Oxygen atoms - C07D 409/06: linked by a carbon chain containing only aliphatic carbon atoms - A01G 17/02: Cultivation of hops or vines - A01G 22/05: Fruit crops, e.g. strawberries, tomatoes or cucumbers - A01G 22/50: Cotton - A01G 22/60: Flowers; Ornamental plants - A01G 23/00: Forestry - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - A01G: HORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING (picking of fruits, vegetables, hops or the like A01D46/00; propagating unicellular algae C12N1/12) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08) ## Abstract The present invention relates to the use of specific active substances, alone or in combination, for controlling virus infections in plants and to a method for using said specific active substances for controlling said virus infections in the field of plant protection and the protection of materials. ## Claims ### Claim 1 A method for controlling viral disease in plants, comprising applying to the plants at least one compound of formula (I): wherein R1 is a thienyl or phenyl, wherein said thienyl or phenyl may be substituted with one or more substituents independently selected from the group consisting of halogen, (C1-C6)alkyl, (C1-C6)alkylthio, ((C1-C6)alkoxy)(C1-C6)alkyl, ((C1-C6)alkylthio)(C1-C6)alkyl and phenyl; and R2 is a phenyl which may be substituted with one or more substituents independently selected from the group consisting of halogen, (C1-C6)alkyl and (C1-C6)alkoxy. ### Claim 2 (depends on 1) The method according to claim 1, wherein R1 is selected from the group consisting of 2-thienyl, phenyl, 3-methyl-2-thienyl, 5-methyl-2-thienyl, 2-methylphenyl, 4-methylphenyl, 4-phenyl-2-thienyl, 5-phenyl-2-thienyl, 4-bromo-2-thienyl, 5-bromo-2-thienyl, 5-chloro-2-thienyl, 4-bromo-5-methyl-2-thienyl, 4-bromo-5-ethyl-2-thienyl, 3-(methyl sulfanyl)-2-thienyl, 4-bromo-5-[(methylsulfanyl)methyl]-2-thienyl, 3-(methoxymethyl)-2-thienyl, 2,6-dimethylphenyl, 2,4,5-trimethylphenyl, 2,4,6-trimethylphenyl and 2,6-dichlorophenyl. ### Claim 3 (depends on 1) The method according to claim 1, wherein R2 is selected from the group consisting of phenyl, 2-chlorophenyl, 2-fluorophenyl, 3-chlorophenyl, 4-fluorophenyl, 2,3-dichlorophenyl, 2,4-dichlorophenyl, 2,5-dichlorophenyl, 3,4-dichlorophenyl, 2-chloro-5-fluorophenyl, 2-methylphenyl, 4-methylphenyl, 2-methoxyphenyl, 3-methoxyphenyl and 4-methoxyphenyl. ### Claim 4 (depends on 1) The method according to claim 1, wherein the control is based on a stimulation of the natural defense mechanism of plants against viruses. ### Claim 5 (depends on 4) The method according to claim 4, wherein the natural defense mechanism of plants against viruses is a RNA-silencing based plant defense mechanism. ### Claim 6 (depends on 1) The method according to claim 1, wherein said method is a preventive method. ### Claim 7 (depends on 1) The method according to claim 1, wherein said plants are selected from the group consisting of cotton, flax, grapevine, fruit, vegetables, crop plants, ornamental plants for gardens and wooded area and genetically modified varieties of each of these plants. ### Claim 8 (depends on 1) The method according to claim 1, wherein said plants are selected from the group consisting of Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp., Rubiaceae sp., Theaceae sp., Sterculiceae sp., Rutaceae sp.; Solanaceae sp., Liliaceae sp., Asteraceae sp., Umbelliferae sp., Cruciferae sp., Chenopodiaceae sp., Cucurbitaceae sp., Alliaceae sp., Papilionaceae sp., Asteraceae sp., Brassicaceae sp., Fabacae sp., Papilionaceae sp., Solanaceae sp. and Chenopodiaceae sp. ### Claim 9 (depends on 1) The method according to claim 1, wherein said viruses are selected from the group consisting of the following families or genus: Caulimoviridae, Geminiviridae, Bromoviridae, Closteroviridae, Comoviridae Potyviridae, Sequiviridae, Tombusviridae, Rhabdoviridae, Bunyaviridae, Partitiviridae, Rheoviridae, Capillovirus, Carlavirus, Enamovirus, Furovirus, Hordeivirus, Idaeovirus, Luteovirus, Marafivirus, Potexvirus, Sobemovirus, Tenuivirus, Tobamovirus, Tobravirus, Trichovirus, Tymovirus and Umbravirus. ### Claim 10 (depends on 1) The method according to claim 1, wherein said viruses are selected from the group consisting of Turnip mosaic virus, turnip crinkle virus, bean pod mottle virus, cauliflower mosaic virus, tobacco mosaic virus, tomato bushy stunt virus, rice ragged stunt virus, cucumber mosaic virus, barley yellow dwarf virus, beet yellows virus, lettuce yellows virus, maise mosaic virus, peanut stunt virus and potato virus Y. ### Claim 11 (depends on 1) The method according to claim 1, wherein the compound of formula (I) is applied by spraying to the plants. ### Claim 12 (depends on 1) The method according to claim 1, wherein the compound of formula (I) is applied to the plants in an amount ranging from 0.01 to 5 kg/ha. ### Claim 13 (depends on 1) The method according to claim 1, wherein R1 is selected from the group consisting of 2-methylphenyl, 4-methylphenyl, 2,6-dimethylphenyl, 2,4,5-trimethylphenyl, 2,4,6-trimethylphenyl and 2,6-dichlorophenyl. ### Claim 14 (depends on 13) The method according to claim 13, wherein R2 is 2-chlorophenyl.