Biodosimetry panels and methods
AssigneesMeso Scale Technologies, LLC., The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
InventorsWilliam F Blakely, Eli N. Glezer, John Kenten, Sudeep Kumar, Anu Mathew, Natalia I. Ossetrova, George Sigal
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Abstract
The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
Claims7
A method of assessing an absorbed dose of ionizing radiation in a plasma or blood sample from a patient, said method comprising
- (a) measuring the level of each of at least six markers in said sample, wherein said at least six markers comprise CD20, Flt-3L, CD177, AMY, IL-12, and TPO;
- (b) applying, by a processor, an algorithm to assess said absorbed dose in said patient as being above or below a 2 Gray (Gy) threshold based on said level of each of said at least six markers in said sample over time with a sensitivity of 96.9% or higher and a specificity of 98.5% or higher;
- (c) grouping the patient into one of two groups, a first group being a group having an assessed absorbed dose below the threshold of 2 Gy, a second group being a group having an assessed absorbed dose above the threshold of 2 Gy;
- and
- (d) administering a medical countermeasure to the patient if the patient is grouped in the second group.
Dependencies are inferred from the claim text.