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US 10,435,721 B2Granted
Xylitol producing metschnikowia species
AssigneeCreatus Biosciences Inc.
InventorsZongli Luo, Hendrik Jurgens Jansen van Vuuren, Allan George DeBono, Andrew Taplin Ferguson
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Abstract
Provided herein are Metschnikowia species that produce xylitol from xylose when cultured, as well as methods to make and use these Metschnikowia species.
Claims35
An isolated Metschnikowia species comprising:
- (a) at least one exogenous nucleic acid encoding a xylose reductase or that results in overexpression of a xylose reductase of the isolated Metschnikowia species;
- and (b) a genetic modification that attenuates or inactivates a xylitol dehydrogenase of the isolated Metschnikowia species, wherein the xylose reductase comprises the amino acid sequence of SEQ ID NO:
- 11 or an amino acid sequence with at least 95% sequence identity to SEQ ID NO:
- 11.
1 more element
Dependencies are inferred from the claim text.