Antibodies to quetiapine and use thereof
AssigneeJanssen Pharmaceutica NV
InventorsEric Hryhorenko, Banumathi Sankaran, Thomas R. DeCory, Theresa Tubbs, Linda Colt, Bart M. Remmerie, Rhys Salter, Matthew G. Donahue, Yong Gong
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Abstract
Disclosed is an antibody or a binding fragment thereof which binds to quetiapine, which can be used to detect quetiapine in a sample such as in a competitive immunoassay method. The antibody or the fragment thereof can be used in a lateral flow assay device for point-of-care detection of quetiapine, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone in a single lateral flow assay device.
Claims25
An isolated antibody or a binding fragment thereof, which specifically binds to quetiapine comprising:
- a) the isolated antibody or the fragment thereof comprising a light chain variable region having an amino acid sequence consisting of SEQ ID NO:3 and a heavy chain variable region having the amino acid sequence consisting of SEQ ID NO:4;
- b) the isolated antibody or the fragment thereof comprising a light chain variable region having an amino acid sequence consisting of SEQ ID NO:8 and a heavy chain variable region having the amino acid sequence consisting of SEQ ID NO:10;
- c) the isolated antibody or the fragment thereof comprising a light chain variable region having an amino acid sequence consisting of SEQ ID NO:9 and a heavy chain variable region having the amino acid sequence consisting of SEQ ID NO:10;
- or
- d) the isolated antibody or the a fragment thereof comprising a light chain variable region having an amino acid sequence consisting of SEQ ID NO:17 and a heavy chain variable region having the amino acid sequence consisting of SEQ ID NO:18.
Dependencies are inferred from the claim text.