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US 10,434,049 B2Granted
Methods of producing compounds that stimulate hair regrowth, topical formulations, and methods of use
AssigneeJoventis, S.A.
InventorReiner Van Tilborg
Life of this patent
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Abstract
A method performing a Friedel-Crafts alkylation reaction between a dichloroalkane and an alkylbenzene produces a compound for hair regrowth. The inventive subject matter further includes incorporation of such compounds in topical formulations with suitable carriers. The resulting topical formulations may be employed in methods of stimulating hair regrowth.
Claims17
A method of producing a composition for hair regrowth, wherein the composition comprises a compound having a structure according to Formula (I)
- the method comprising:
- (1) adding a Friedel-Crafts catalyst to a 1,2-dichloroalkane to generate a first intermediate at a first temperature, wherein the first temperature is between −10 and 15 degrees Celsius, inclusive
- (2) adding the first intermediate to an alkylbenzene at the first temperature and to generate a second intermediate;
- (3) cooling the second intermediate to a second temperature to generate a third intermediate, wherein the second temperature is between −90 and −70 degrees Celsius, inclusive;
- (4) incubating the third intermediate at the second temperature for a first duration;
- (5) warming the third intermediate to a third temperature and incubating the third intermediate at the third temperature for a second duration, wherein the third temperature is between 30 and 50 degrees Celsius, inclusive;
- (6) cooling the third intermediate to the second temperature and incubating the third intermediate at the second temperature for a third duration;
- and
- (7) repeating steps (5) and (6) at least four times.
6 more elements
Dependencies are inferred from the claim text.