Modulation of stimulatory and non-stimulatory myeloid cells
AssigneeThe Regents of the University of California
InventorsMatthew Krummel, Miranda Broz, Denise Wolf, Joshua Pollack, Mikhail Biennewies
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Abstract
Provided herein are methods and compositions for enhancing an immune response and/or for the treatment of an immune-related condition in an individual, e.g., cancer, comprising killing, disabling, or depleting non-stimulatory myeloid cells using an antigen binding protein such as an antibody or antigen binding fragment thereof.
Claims22
A method of killing, disabling, or depleting Triggering Receptor Expressed on Myeloid Cells 2 (TREM2+) myeloid cells present in a cancer tissue of a subject, comprising:
- contacting the TREM2+ myeloid cells present in the cancer tissue of the subject with an antibody or antigen-binding fragment thereof comprising a human Fc domain, wherein the antibody or antigen-binding fragment thereof binds to the extracellular domain of TREM2;
- wherein the antibody or antigen-binding fragment thereof is present in an amount effective to kill, disable, or deplete the TREM2+ myeloid cells via antibody-dependent cell-mediated cytotoxicity activity, antibody-dependent phagocytosis activity, complement-dependent cytotoxicity activity, or antibody-mediated phagocytosis activity.
A method of treating a cancer in a subject, comprising administering to the subject an antibody or antigen-binding fragment thereof comprising a human Fc domain, wherein the antibody or antigen-binding fragment thereof binds to the extracellular domain Triggering Receptor Expressed on Myeloid Cells 2 (TREM2+), wherein TREM2+ myeloid cells are present in the cancer and the antibody or antigen-binding fragment thereof is present in an amount effective to kill, disable, or deplete the TREM2+ myeloid cells via antibody-dependent cell-mediated cytotoxicity activity, antibody-dependent phagocytosis activity, complement-dependent cytotoxicity activity, or antibody-mediated phagocytosis activity.
Dependencies are inferred from the claim text.