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US 10,428,118 B2Granted
Human cytomegalovirus comprising exogenous antigens
AssigneeOregon Health & Science University
InventorsKlaus Frueh, Scott G. Hansen, Jay Nelson, Louis Picker, Patrizia Caposio
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Abstract
Human cytomegalovirus vectors comprising heterologous antigens are disclosed. The vectors derived from the TR strain, are ganciclovir-sensitive, include active US2, US3, US6, US7 and UL131A genes, and have a deleterious or inactivating mutation in the UL82 gene preventing the expression of pp71.
Claims20
A recombinant human cytomegalovirus (HCMV) comprising:
- (1) a nucleic acid encoding at least one heterologous antigen,
- (2) an inactivating mutation in the UL82 gene, and
- (3) active US2, US3, US6, US7, UL131A, and UL97 genes;
- wherein the recombinant HCMV is a genetically modified TR strain of HCMV;
- and the recombinant HCMV is Ganciclovir sensitive.
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