Nanostructure surface coated medical implants and methods of using the same
AssigneesThe Regents of the University of California, The Penn State Research Foundation
InventorsTejal A. Desai, Ketul C. Popat, Craig A. Grimes
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Abstract
Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed. The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.
Claims21
A method comprising administering to a subject a composition that comprises a surface or film comprising a vertically oriented array of a plurality of nanotubes or microwells,
- wherein a bioactive agent is filled into the nanotubes or microwells themselves,
- wherein a first end of the array of the plurality of filled nanotubes or microwells is in contact with the surface or film, and
- wherein the plurality of nanotubes or microwells is capped with a polymeric erodible capping film to provide for delayed elution of the bioactive agent from within the nanotubes or microwells to the surrounding tissue upon placement in a subject and erosion of the capping film.
Dependencies are inferred from the claim text.