Blood collection cartridge, blood collection system, and blood collection method for use thereof

A blood collection cartridge, comprising:

• a container having a distal end, a proximal end, and a sidewall extending therebetween and defining a container interior;
• a resealable closure sealing the distal end of the container, the resealable closure having a closure distal end and a closure proximal end;
• a cap configured to seal the proximal end of the container, the cap having a cap distal end and a cap proximal end, the cap configured to be transitionable between a closed position, in which the cap seals the proximal end of the container, and an open position, in which the cap breaks a liquid and gaseous impermeable seal with the proximal end of the container allowing air to vent from the container interior, the cap configured to be transitionable from the open position to the closed position to reform the liquid and gaseous impermeable seal with the proximal end of the container;
• a stopper configured to be slidably disposed within the container interior of the container, the stopper sized relative to the container to provide sealing engagement with the sidewall of the container, the stopper having a stopper distal end and a stopper proximal end, the stopper configured to contact the sidewall of the container at a first point and a second point spaced from the first point and no other portion of the stopper is configured to contact the sidewall of the container when the stopper is disposed within the container interior of the container, wherein when the cap is in the open position, the cap allows the air to vent from the container interior to allow for movement of the stopper in the container interior of the container;
• a first fluid reservoir located within the sidewall between the closure proximal end and the stopper distal end, wherein the first fluid reservoir is a fluid-tight reservoir formed by the sidewall, the closure proximal end, and the stopper distal end;
• and
• a second fluid reservoir located within the sidewall between the cap distal end and the stopper proximal end,
• wherein the stopper is configured to move toward the proximal end of the container due to a force caused by a pressure applied by fluid in the first fluid reservoir when the cap is in the open position, and to maintain a fluid-tight seal formed by the sidewall and the stopper distal end when moving toward the proximal end of the container such that the fluid remains contained in the first fluid reservoir.

A blood collection cartridge, comprising:

• a container having a distal end, a proximal end, and a sidewall extending therebetween and defining a container interior;
• a resealable closure sealing the distal end of the container, the resealable closure having a closure distal end and a closure proximal end;
• a cap sealing the proximal end of the container, the cap having a cap distal end and a cap proximal end, the cap rotatable between a closed position in which the cap seals the proximal end of the container and an open position in which the cap breaks a liquid and gaseous impermeable seal with the proximal end of the container allowing air to vent from the container interior, the cap transitionable from the open position to the closed position to reform the liquid and gaseous impermeable seal with the proximal end of the container;
• a spacing member having a protruding portion extending from the cap distal end along a container longitudinal axis of the container into the container interior;
• a stopper slidably disposed within the container interior of the container, the stopper sized relative to the container to provide sealing engagement with the sidewall of the container, the stopper having a stopper distal end and a stopper proximal end, wherein when the cap is in the open position, the cap allows the air to vent from the container interior to allow for movement of the stopper in the container interior of the container;
• a first fluid reservoir located within the sidewall between the closure proximal end and the stopper distal end, wherein the first fluid reservoir is a fluid-tight reservoir formed by the sidewall, the closure proximal end, and the stopper distal end;
• a second fluid reservoir located within the sidewall between the cap distal end and the stopper proximal end;
• and
• an anticoagulant disposed within the first fluid reservoir, wherein the stopper is slidable between a distal position in which the stopper is adjacent the closure proximal end such that the anticoagulant completely fills the first fluid reservoir and a proximal position in which the stopper abuts the spacing member,
• wherein the stopper is configured to move toward the proximal end of the container due to a force caused by a pressure applied by fluid in the first fluid reservoir when the cap is in the open position, and to maintain a fluid-tight seal formed by the sidewall and the stopper distal end when moving toward the proximal end of the container such that the fluid remains contained in the first fluid reservoir.

A blood collection system, comprising:

• a blood collection cartridge, comprising:
• a container having a distal end, a proximal end, and a sidewall extending therebetween and defining a container interior,
• a resealable closure sealing the distal end of the container, the resealable closure having a closure distal end and a closure proximal end,
• a cap sealing the proximal end of the container, the cap having a cap distal end and a cap proximal end, the cap transitionable between a closed position, in which the cap seals the proximal end of the container, and an open position, in which the cap breaks a liquid and gaseous impermeable seal with the proximal end of the container allowing air to vent from the container interior, the cap transitionable from the open position to the closed position to reform the liquid and gaseous impermeable seal with the proximal end of the container,
• a stopper slidably disposed within the container interior of the container, the stopper sized relative to the container to provide sealing engagement with the sidewall of the container, the stopper having a stopper distal end and a stopper proximal end, wherein when the cap is in the open position, the cap allows the air to vent from the container interior to allow for movement of the stopper in the container interior of the container,
• a first fluid reservoir located within the sidewall between the closure proximal end and the stopper distal end, wherein the first fluid reservoir is a fluid-tight reservoir formed by the sidewall, the closure proximal end, and the stopper distal end,
• a second fluid reservoir located within the sidewall between the cap distal end and the stopper proximal end, and
• an anticoagulant disposed within the first fluid reservoir;
• a needle assembly, comprising:
• a hub configured to provide a visual indication of flashback of a fluid flowing into the hub, and
• at least one cannula having a cannula distal end and a cannula proximal end, a portion of the at least one cannula mounted within the hub;
• and
• a holder attached to the needle assembly, such that with the blood collection cartridge inserted within the holder and connected with the needle assembly the cannula proximal end pierces the resealable closure of the blood collection cartridge, thereby providing the first fluid reservoir and the at least one cannula in fluid communication,
• wherein the stopper is configured to move toward the proximal end of the container due to a force caused by a pressure applied by the fluid in the first fluid reservoir when the cap is in the open position, and to maintain a fluid-tight seal formed by the sidewall and the stopper distal end when moving toward the proximal end of the container, such that the fluid remains contained in the first fluid reservoir.