Nanofiber mats, method of manufacturing the nanofiber mats, and applications to cell culture and nanofibrous membrane for guided bone regeneration

A nanofiber mat, comprising:

• a nanofiber layer;
• and
• a reinforcement pattern that is disposed on the nanofiber layer,
• wherein the nanofiber layer and the reinforcement pattern are combined with each other through an interface formed by melting-solidification of at least a part of the nanofiber layer together with the reinforcement pattern such that the interface comprises at least a portion of melted nanofiber layer and at least a portion of melted reinforcement pattern;
• wherein the reinforcement pattern fills between a surface, on which the reinforcement pattern is formed, and a back surface of the nanofiber layer at least partially so that a migration of a material is restricted by the reinforcement pattern,
• wherein the nanofiber mat has a planar shape and the thickness of the nanofiber layer ranges from 10 nm to 10 μm;
• wherein the reinforcement pattern includes at least two subpatterns having mutually different shapes, and rigidity of regions in which the subpatterns are formed are mutually different;
• and
• wherein the subpatterns have a shape of at least one selected among a square lattice, a circular lattice, a rhombic lattice, a zigzag, and a curve.