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US 10,420,846 B2Granted
Bifunctional polypeptides
AssigneeImmunocore Limited
InventorsBent Karsten Jakobsen, Annelise Brigitte Vuidepot, Yi Li
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Abstract
A bifunctional polypeptide comprising a specific binding partner for a peptide-MHC epitope, such as an antibody or T cell receptor, and an immune effector, such as an antibody or a cytokine, the immune effector part being linked to the N-terminus of the peptide-MHC binding part.
Claims5
A bifunctional molecule, comprising:
- (i) a polypeptide binding partner, wherein the polypeptide binding partner binds specifically to a given pMHC epitope, and
- (ii) an immune effector polypeptide,
- wherein:
- the N-terminus of the pMHC binding partner is linked to the C-terminus of the immune effector polypeptide,
- the pMHC binding partner is a single chain antibody (scFv), and
- the immune effector polypeptide is a single chain anti-CD3 antibody.
3 more elements
Dependencies are inferred from the claim text.