Compositions and methods relating to salts of specialized pro-resolving mediators

A compound of Formula IV which contains a scaffold of two amino acid moieties coordinated around a divalent metal and one or two SPM molecules A, B, ionically bound to at least one basic function provided by the scaffold:

• wherein
• M is a divalent metal selected from magnesium (Mg2+) and calcium (Ca2+),
• A and B are each independently an SPM molecule selected from an E series resolvin, a D series resolvin, and their aspirin-triggered counterparts,
• A and B may be the same or different,
• either A or B, but not both, may be absent,
• R1 and R2 are each independently —(CH2)3—Y1, and —(CH2)4—Y2,
• where Y1 and Y2 are each a basic function selected from a positively charged primary amine, a positively charged secondary amine, a positively charged tertiary amine, and a positively charged guanidine,
• X1 and X2 are each independently H or CO—Z and Z is a peptide comprising 1 to 5 amino acids.