Nanocapsules carrying chikungunya-associated peptides
AssigneesAgency for Science, Technology and Research, Nanyang Technological University
InventorsFong Poh Lisa Ng, Yiu-Wing Jason Kam, Wei Ling Wendy Lee, Fok Moon Lum, Sierin Lim, Kang Yu, Chengxun Su
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Abstract
The present invention refers to a composition comprising a viral protein or fragment thereof, wherein the viral protein or fragment thereof is enclosed within a self-assembling protein nanocapsule, preferably ferritin, and wherein the viral protein, or fragment thereof is selected from a virus of the Togaviridae family. The viral protein or fragment thereof may also further be selected from a virus of the alphavirus subfamily.
Claims18
A composition comprising a viral protein or fragment thereof, wherein the viral protein, or fragment thereof is enclosed within a nanocapsule, and wherein the viral protein, or fragment thereof is selected from a virus of the Togaviridae family, wherein the nanocapsule is formed by a scaffold protein, wherein the scaffold protein is a mutated ferritin protein encoded by SEQ ID NO. 13 or SEQ ID NO. 14.
A nucleic acid sequence comprising a gene encoding a viral protein or fragment thereof, a linker sequence and a scaffold protein;
- wherein the viral protein, or fragment thereof is enclosed within a nanocapsule, and wherein the viral protein, or fragment thereof is selected from a virus of the Togaviridae family, wherein the nanocapsule is formed by a scaffold protein, wherein the scaffold protein is a mutated ferritin protein encoded by SEQ ID NO. 13 or SEQ ID NO. 14.
Dependencies are inferred from the claim text.