Chlamydia vaccine
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsHarlan D. Caldwell, Deborah Crane
Life of this patent
Estimating the term…
Abstract
Compositions and methods for the treatment of Chlamydial infection are disclosed. The compositions provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions, vaccines and diagnostic kits are also disclosed.
Claims12
An immunogenic composition for inducing neutralizing antibodies against Chlamydia trachomatis in a subject, comprising:
- (A) at least one isolated polypeptide comprising a passenger domain of PmpD of Chlamydia trachomatis and (B) an adjuvant in an immunostimulatory amount, wherein the polypeptide is in an amount effective for inducing a neutralizing antibody immune response in the subject, wherein the passenger domain of PmpD is from Chlamydia trachomatis serovar A and comprises the amino acid sequence of SEQ ID NOs:
- 4 or 7.
An immunogenic composition for inducing neutralizing antibodies against Chlamydia trachomatis in a subject, comprising:
- (A) at least one isolated polypeptide (1) comprising the amino acid sequence of SEQ ID NO:
- 6 or (2) consisting of the amino acid sequence of SEQ ID NO:
- 9 and (B) an adjuvant in an immunostimulatory amount, wherein the polypeptide is in an amount effective for inducing a neutralizing antibody immune response in the subject.
Dependencies are inferred from the claim text.