Targets of acinetobacter baumannii
OwnerSimon Urwyler, Markus Haake +1inventors
InventorsSimon Urwyler, Markus Haake, Michael Rudolf
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Abstract
The present invention provides antigenic polypeptides expressed during an infection by a pathogenic organism, such as Acinetobacter and compositions comprising these polypeptides. The invention further provides compositions for use in treating, preventing or detecting a bacterial infection, in particular vaccine compositions using the antigenic polypeptides. The invention further provides antibodies directed to said antigenic polypeptides.
Claims6
An immunogenic composition comprising:
- an isolated polypeptide encoded by a recombinant nucleic acid molecule consisting of the polynucleotide sequence of SEQ ID NO:
- 11;
- and,
- an immuno-effective amount of an adjuvant;
- wherein the composition is effective in generating an immune response against Acinetobacter baumannii in a subject in need thereof.
An immunogenic composition comprising:
- an isolated recombinant antigenic polypeptide consisting of the amino acid sequence of SEQ ID NO:
- 12 having immunostimulatory activity in combination with an immuno-effective amount of an adjuvant.
An isolated recombinant polypeptide consisting of:
- an amino acid sequence which is encoded by a polynucleotide sequence which consists of the nucleic acid sequence of SEQ ID NO:
- 11 and a nucleic acid sequence encoding a His tag;
- or
- an amino acid sequence consisting of the sequence of SEQ ID NO:
- 12 and a His tag.
An immunogenic composition comprising:
- an isolated recombinant antigenic polypeptide consisting of the amino acid sequence SEQ ID NO:
- 12 plus a His tag having immunostimulatory activity in combination with an immuno-effective amount of an adjuvant.
Dependencies are inferred from the claim text.