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US 10,420,817 B2Granted
Compositions and methods for inhibiting the biological activity of soluble biomolecules
AssigneeNaNotics, LLC
InventorLouis Hawthorne
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Abstract
The disclosure provides, among other things, compositions that bind to and inhibit the biological activity of soluble biomolecules, as well as pharmaceutical compositions thereof. Also provided herein are a number of applications (e.g., therapeutic applications) in which the compositions are useful.
Claims25
A particle having at least one surface and an agent immobilized on the surface, wherein:
- the agent selectively binds to a target that is a first member of a specific binding pair;
- binding of the target to the particle inhibits the interaction of the target with a second member of the specific binding pair;
- the target is a soluble biomolecule;
- the soluble biomolecule is a form of a cell surface protein;
- and
- the agent is disposed on a surface of the particle such that it is sterically inhibited from binding or activating the cell surface protein on the surface of a cell.
3 more elements
Dependencies are inferred from the claim text.