Combinational therapy for synergistic inhibition of gram-positive and gram-negative bacteria
AssigneeThe Governors of the University of Alberta
InventorsByeonghwa Jeon, Jong-Chul Kim
Life of this patent
Estimating the term…
Abstract
Compositions and methods for inhibiting the growth of Gram-negative and/or Gram-positive bacteria and pharmaceutical compositions for treating infections of such bacteria in humans and animals are provided. An exemplary method for inhibiting the growth of Gram-negative and/or Gram-positive bacteria includes contacting the bacteria or an environment containing the bacteria with a combination of bacitracin and a gallate ester. An exemplary pharmaceutical composition includes bacitracin and a gallate ester.
Claims20
A method for inhibiting the growth of Gram-negative and/or Gram-positive bacteria which comprises contacting the bacteria or an environment containing the bacteria with a combination of bacitracin and a gallate ester, wherein the gallate ester is octyl gallate, lauryl gallate or an aryl gallate ester.
A method for inhibiting the growth of Gram-negative bacteria which comprises contacting the bacteria or an environment containing the bacteria with a combination of bacitracin and a gallate ester.
A method of treating a bacterial infection in an individual in need of such treatment which comprises administering to the individual a combined effective amount of bacitracin and a gallate ester, wherein the gallate ester is octyl gallate, lauryl gallate or an aryl gallate ester.
A method of treating a bacterial infection in an individual in need of such treatment which comprises administering to the individual a combined effective amount of bacitracin and a gallate ester, wherein the infection is a Gram-negative bacterial infection.
A pharmaceutical composition which comprises bacitracin and a gallate ester, wherein the gallate ester is octyl gallate, lauryl gallate or an aryl gallate ester.
Dependencies are inferred from the claim text.