Competitive inhibitors of invariant chain expression and/or ectopic clip binding
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsMartha Karen Newell-Rogers, Evan Newell
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Abstract
The invention relates to methods for modulating the immune function through targeting of CLIP molecules. The result is wide range of new therapeutic regimens for treating, inhibiting the development of, or otherwise dealing with, a multitude of illnesses and conditions, including autoimmune disease, cancer, Alzheimer's disease, allergic disease, transplant and cell graft rejection, HIV infection and other viral, bacterial, and parasitic infection, and AIDS. Methods are also provided for preparing a peptide having the property of being able to displace CLIP by feeding one or more peptide sequences into software that predicts MHC Class II binding regions in an antigen sequence and related products.
Claims12
A synthesized peptide comprising FRIM X4VLX6S (SEQ ID NO:
- 6), wherein X4 and X6 are any amino acid, and wherein the peptide is a CLIP displacer, wherein the peptide has 9-20 amino acids.
An isolated peptide comprising FRIMAVLAS (SEQ ID NO:
- 2).
Dependencies are inferred from the claim text.