Therapeutic compositions and uses thereof
AssigneeManuka Health New Zeland Limited
InventorsKerry Paul, Owen John Catchpole, Darina Lazarova
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Abstract
This invention provides pharmaceutical compositions, including anti-gastrointestinal cancer compositions, containing propolis and cyclodextrin. Methods of using such compositions, in particular in the treatment or prevention of gastrointestinal cancers, and the resensitization of gastrointestinal cancers to therapy are also provided.
Claims16
A method of treating gastric cancer in a subject, the method comprising administration of an effective amount of a composition comprising propolis and cyclodextrin, to a subject in need thereof, wherein
- (a) the propolis is a propolis extract or fraction,
- (b) the composition comprises a CAPE concentration of from about 1 to about 5 mg/g and a pinocembrin concentration of greater than about 10 mg/g,
- (c) the propolis extract or fraction is entirely encapsulated within the cyclodextrin, and
- (d) the cyclodextrin is gamma-cyclodextrin or chemically modified gamma-cyclodextrin.
A method of ameliorating the onset or severity of symptoms of gastric cancer in a subject or maintaining symptoms of gastric cancer at a substantially static level in a subject, the method comprising administration of an effective amount of a composition comprising propolis and cyclodextrin, to a subject in need thereof, wherein
- (a) the propolis is a propolis extract or fraction,
- (b) the composition has a CAPE concentration of from about 1 to about 5 mg/g and a pinocembrin concentration of greater than about 10 mg/g,
- (c) the propolis extract or fraction is entirely encapsulated within the cyclodextrin, and
- (d) the cyclodextrin is gamma-cyclodextrin or chemically modified gamma-cyclodextrin.
Dependencies are inferred from the claim text.