Isolation and use of human lymphoid organ-derived suppressive stromal cells
AssigneesThe General Hospital Corporation, Dana-Farber Cancer Institute, Inc.
InventorsAnne Fletcher, Shannon J. Turley, Biju Parekkadan
Life of this patent
Estimating the term…
Abstract
A method for suppressing an immune response is provided. The method involves administration of isolated lymphoid tissue-derived suppressive stromal cells (LSSC) to a subject in need of such treatment in an amount effective to suppress the immune response in the subject. The invention also involves a method to isolate LSSC by digesting lymphoid tissue fragments using a combination of an enzyme mix and agitation and then collecting the LSSC. Pharmaceutical preparations comprising LSSC are also provided.
Claims20
A method for suppressing an immune response comprising:
- administering to a subject in need of such treatment isolated lymphoid tissue-derived suppressive stromal cells (LSSC), wherein the LSSCs are fibroblastic reticular cells (FRCs) in an amount effective to suppress the immune response in the subject, and wherein the FRCs are passaged.
Dependencies are inferred from the claim text.